Biology:D-alanine 2-hydroxymethyltransferase
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D-alanine 2-hydroxymethyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.1.2.7 | ||||||||
CAS number | 9075-76-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a D-alanine 2-hydroxymethyltransferase (EC 2.1.2.7) is an enzyme that catalyzes the chemical reaction
- 5,10-methylenetetrahydrofolate + D-alanine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] tetrahydrofolate + 2-methylserine
The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, D-alanine, and H2O, whereas its two products are tetrahydrofolate and 2-methylserine.
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase. This enzyme is also called 2-methylserine hydroxymethyltransferase. This enzyme participates in one carbon pool by folate.
References
- "Metabolism of alpha-methylserine. I. alpha-Methylserine hydroxymethyltransferase". The Journal of Biological Chemistry 237: 3171–9. October 1962. PMID 14001018.
![]() | Original source: https://en.wikipedia.org/wiki/D-alanine 2-hydroxymethyltransferase.
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