Biology:DLEU2

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Short description: Non-coding RNA in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Deleted in lymphocytic leukemia 2 (non-protein coding) is a long non-coding RNA that in humans is encoded by the DLEU2 gene. In humans it is located on chromosome 13q14.[1][2][3] The DLEU2 gene was originally identified as a potential tumour suppressor gene and is often deleted in patients with B-cell chronic lymphocytic leukemia.[1]

See also

References

  1. ↑ 1.0 1.1 "Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia". Oncogene 15 (20): 2463–2473. Nov 1997. doi:10.1038/sj.onc.1201643. PMID 9395242. 
  2. ↑ "BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like". International Journal of Cancer 88 (5): 692–697. Dec 2000. doi:10.1002/1097-0215(20001201)88:5<692::AID-IJC2>3.0.CO;2-3. PMID 11072235. 
  3. ↑ "Entrez Gene: DLEU2 deleted in lymphocytic leukemia, 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8847. 

Further reading

  • "Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14". Genomics 70 (3): 327–334. Dec 2000. doi:10.1006/geno.2000.6386. PMID 11161783. 
  • "Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia". Blood 97 (7): 2098–2104. Apr 2001. doi:10.1182/blood.V97.7.2098. PMID 11264177. 
  • "Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene". Cancer Research 61 (18): 6640–6648. Sep 2001. PMID 11559527. 
  • "Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse: multiple mRNA isoforms in both species- and human-specific antisense transcript RFP2OS". Gene 321: 103–112. Dec 2003. doi:10.1016/j.gene.2003.08.007. PMID 14636997. 
  • "DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse". Genes, Chromosomes & Cancer 40 (4): 285–297. Aug 2004. doi:10.1002/gcc.20046. PMID 15188451. 
  • "Human RFP2 gene promoter: unique structure and unusual strength". Biochemical and Biophysical Research Communications 342 (3): 859–866. Apr 2006. doi:10.1016/j.bbrc.2006.01.187. PMID 16499869. 



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