Biology:ELM2 domain
From HandWiki
| ELM2 domain | |
|---|---|
| Identifiers | |
| Symbol | ELM2 |
| InterPro | IPR000949 |
| PROSITE | PDOC51156 |
The ELM2 domain is a protein motif found in transcriptional corepressors such as CoREST and MTA1. The name ELM2 is an acronym standing for Egl-27 and MTA1 homology 2.[1] This domain helps recruit HDAC proteins to corepression complexes to further down regulate gene expression by making chromatin less accessible through deacetylating of histones.[2]
References
- ↑ "Towards an understanding of the structure and function of MTA1". Cancer Metastasis Reviews 33 (4): 857–867. December 2014. doi:10.1007/s10555-014-9513-5. PMID 25352341.
- ↑ "Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain". Molecular and Cellular Biology 23 (1): 250–258. January 2003. doi:10.1128/MCB.23.1.250-258.2003. PMID 12482978.
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