Biology:EZH1
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 Generic protein structure example |
Histone-lysine N-methyltransferase EZH1 is an enzyme that in humans is encoded by the EZH1 gene.[1][2]
Function
In mice, EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.[3] EZH1 also complements EZH2 in maintaining stem cell identity and executing pluripotency.[4]
References
- ↑ "Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1". Genomics 37 (2): 161–71. Feb 1997. doi:10.1006/geno.1996.0537. PMID 8921387.
- ↑ "Entrez Gene: EZH1 enhancer of zeste homolog 1 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2145.
- ↑ "EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.". Genes Dev. 25 (5): 485–98. Mar 2011. doi:10.1101/gad.2019811. PMID 21317239.
- ↑ "EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.". Mol Cell 32 (4): 491–502. Nov 2008. doi:10.1016/j.molcel.2008.10.016. PMID 19026780.
Further reading
- "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.". Genomics 28 (3): 530–42. 1996. doi:10.1006/geno.1995.1185. PMID 7490091.
- "Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17.". Genomics 25 (1): 238–47. 1995. doi:10.1016/0888-7543(95)80131-5. PMID 7774924. https://zenodo.org/record/1258609.
- "Direct selection of expressed sequences within a 1-Mb region flanking BRCA1 on human chromosome 17q21.". Genomics 25 (1): 248–55. 1995. doi:10.1016/0888-7543(95)80132-6. PMID 7774925.
- "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors.". Genomics 25 (1): 256–63. 1995. doi:10.1016/0888-7543(95)80133-7. PMID 7774926.
- "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. 1997. doi:10.1093/dnares/4.2.141. PMID 9205841.
- "Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2.". Biochim. Biophys. Acta 1395 (2): 151–8. 1998. doi:10.1016/s0167-4781(97)00156-5. PMID 9473645.
- "The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression.". Mol. Cell. Biol. 18 (5): 2825–34. 1998. doi:10.1128/mcb.18.5.2825. PMID 9566901.
- "Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.". Mol. Cell. Biol. 18 (6): 3572–9. 1998. doi:10.1128/MCB.18.6.3572. PMID 9584197.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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