Biology:GGL domain
From HandWiki
 Phosducin - transducin beta-gamma complex. Gamma subunit (GGL domain) colored red. | |||||||||||
| Identifiers | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Symbol | G-gamma | ||||||||||
| Pfam | PF00631 | ||||||||||
| InterPro | IPR001770 | ||||||||||
| SMART | GGL | ||||||||||
| PROSITE | PDOC01002 | ||||||||||
| SCOP2 | 1gp2 / SCOPe / SUPFAM | ||||||||||
| OPM protein | 2bcj | ||||||||||
| CDD | cd00068 | ||||||||||
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GGL domain is domain found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling RGS proteins.[1]
Human proteins containing this domain
- GNG4; GNG10; GNG11
- GNGT1
- RGS6; RGS7; RGS9; RGS11
See also
- Beta-gamma complex
References
- ↑ "A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13307–12. 1998. doi:10.1073/pnas.95.22.13307. PMID 9789084. Bibcode: 1998PNAS...9513307S.
Further reading
- "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants". J. Biol. Chem. 278 (32): 30261–71. August 2003. doi:10.1074/jbc.M212687200. PMID 12761221.
- "Instability of GGL domain-containing RGS proteins in mice lacking the G protein β-subunit Gβ5". Proc. Natl. Acad. Sci. U.S.A. 100 (11): 6604–9. May 2003. doi:10.1073/pnas.0631825100. PMID 12738888. Bibcode: 2003PNAS..100.6604C.
- "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J. Biol. Chem. 277 (40): 37832–9. October 2002. doi:10.1074/jbc.M205908200. PMID 12140291.
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