Biology:GPS2 (gene)

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.[1][2]

Function

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.[2]

Interactions

GPS2 (gene) has been shown to interact with:

References

  1. "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells". Molecular and Cellular Biology 16 (12): 6698–706. Dec 1996. doi:10.1128/mcb.16.12.6698. PMID 8943324. 
  2. 2.0 2.1 "Entrez Gene: GPS2 G protein pathway suppressor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2874. 
  3. "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. 
  4. "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". The Journal of Biological Chemistry 279 (32): 33727–41. Aug 2004. doi:10.1074/jbc.M401708200. PMID 15159402. 
  5. "AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins". Journal of Virology 74 (13): 5872–9. Jul 2000. doi:10.1128/jvi.74.13.5872-5879.2000. PMID 10846067. 
  6. 6.0 6.1 6.2 "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Molecular Cell 9 (3): 611–23. Mar 2002. doi:10.1016/s1097-2765(02)00468-9. PMID 11931768. 
  7. "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell 12 (3): 723–34. Sep 2003. doi:10.1016/j.molcel.2003.08.008. PMID 14527417. 
  8. "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". The EMBO Journal 22 (6): 1336–46. Mar 2003. doi:10.1093/emboj/cdg120. PMID 12628926. 
  9. "AMF1 (GPS2) modulates p53 transactivation". Molecular and Cellular Biology 21 (17): 5913–24. Sep 2001. doi:10.1128/mcb.21.17.5913-5924.2001. PMID 11486030. 

Further reading