Biology:Nuclear receptor co-repressor 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.[1][2]
NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of gene expression.[1][3]
Loss of function of this protein significantly increases the strength and power of mouse muscles.[4]
Family
It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 2.[5]
Interactions
Nuclear receptor co-repressor 1 has been shown to interact with:
- Androgen receptor,[6][7][8][9]
- CHD1,[10]
- Calcitriol receptor[11][12]
- GPS2,[13][14][15]
- Glucocorticoid receptor,[16][17]
- HDAC3,[13][14][15][18][19][20][21]
- HDAC4,[20][22]
- HDAC7A,[18]
- HDAC9,[23]
- HEY2,[24]
- Histone deacetylase 5,[13][22]
- MAP3K7IP2,[25]
- MECP2,[26]
- Peroxisome proliferator-activated receptor alpha,[27]
- Peroxisome proliferator-activated receptor gamma
- Promyelocytic leukemia protein,[28]
- RUNX1T1,[29][30]
- Retinoic acid receptor alpha,[27][31]
- Retinoic acid receptor gamma,[27]
- SAP30,[21][32]
- TBL1XR1,[13][14][15]
- TBL1X,[13][15][19][33] and
- ZBTB33.[14]
Further reading
- "Retinoid receptors in health and disease: co-regulators and the chromatin connection.". Semin. Cell Dev. Biol. 10 (2): 215–25. 1999. doi:10.1006/scdb.1999.0303. PMID 10441075.
- "Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors.". Nucleic Acids Res. 24 (22): 4379–86. 1997. doi:10.1093/nar/24.22.4379. PMID 8948627.
- "Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone.". Mol. Cell. Biol. 17 (5): 2642–8. 1997. doi:10.1128/mcb.17.5.2642. PMID 9111334.
- "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14400–5. 1998. doi:10.1073/pnas.94.26.14400. PMID 9405624.
- "Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha.". Mol. Endocrinol. 12 (2): 248–62. 1998. doi:10.1210/mend.12.2.0061. PMID 9482666.
- "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.". Blood 91 (8): 2634–42. 1998. doi:10.1182/blood.V91.8.2634.2634_2634_2642. PMID 9531570.
- "A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.". Genes Dev. 12 (15): 2269–77. 1998. doi:10.1101/gad.12.15.2269. PMID 9694793.
- "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.". Mol. Cell 2 (1): 33–42. 1998. doi:10.1016/S1097-2765(00)80111-2. PMID 9702189.
- "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10860–5. 1998. doi:10.1073/pnas.95.18.10860. PMID 9724795. Bibcode: 1998PNAS...9510860W.
- "Unique forms of human and mouse nuclear receptor corepressor SMRT.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2639–44. 1999. doi:10.1073/pnas.96.6.2639. PMID 10077563. Bibcode: 1999PNAS...96.2639O.
- "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein.". J. Biol. Chem. 274 (22): 15901–7. 1999. doi:10.1074/jbc.274.22.15901. PMID 10336495.
- "Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin.". Hum. Mol. Genet. 8 (9): 1647–55. 2000. doi:10.1093/hmg/8.9.1647. PMID 10441327.
- "Localization of the human nuclear receptor corepressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2.". Genomics 59 (3): 339–41. 1999. doi:10.1006/geno.1998.5694. PMID 10444336.
- "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. 1999. doi:10.1093/dnares/6.3.197. PMID 10470851.
- "The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors.". Nature 402 (6757): 93–6. 1999. doi:10.1038/47069. PMID 10573424. Bibcode: 1999Natur.402...93H.
- "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.". Genes Dev. 14 (1): 45–54. 2000. doi:10.1101/gad.14.1.45. PMID 10640275.
- "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1.". Gene 241 (2): 287–95. 2000. doi:10.1016/S0378-1119(99)00481-3. PMID 10675041.
- "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR.". Oncogene 19 (12): 1538–46. 2000. doi:10.1038/sj.onc.1203421. PMID 10734313.
References
- ↑ 1.0 1.1 "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor". Nature 377 (6548): 397–404. October 1995. doi:10.1038/377397a0. PMID 7566114. Bibcode: 1995Natur.377..397H.
- ↑ "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10860–5. September 1998. doi:10.1073/pnas.95.18.10860. PMID 9724795. Bibcode: 1998PNAS...9510860W.
- ↑ "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc Natl Acad Sci USA 95 (18): 10860–5. 1998. doi:10.1073/pnas.95.18.10860. PMID 9724795. Bibcode: 1998PNAS...9510860W.
- ↑ "NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function". Cell 147 (4): 827–839. 2011. doi:10.1016/j.cell.2011.10.017. PMID 22078881.
- ↑ UniProt Nuclear receptor corepressors family Page accessed June 26, 2016
- ↑ "Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells". Mol. Endocrinol. 18 (10): 2388–401. October 2004. doi:10.1210/me.2003-0436. PMID 15256534.
- ↑ "Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor". Mol. Endocrinol. 18 (1): 70–85. January 2004. doi:10.1210/me.2003-0189. PMID 14593076.
- ↑ "Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor". Mol. Endocrinol. 16 (7): 1492–501. July 2002. doi:10.1210/mend.16.7.0870. PMID 12089345.
- ↑ "The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists". J. Biol. Chem. 280 (8): 6511–9. February 2005. doi:10.1074/jbc.M408972200. PMID 15598662.
- ↑ "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. 308 (1): 170–6. August 2003. doi:10.1016/s0006-291x(03)01354-8. PMID 12890497.
- ↑ "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res. 62 (23): 7050–8. December 2002. PMID 12460926.
- ↑ "The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators". Biochem. Biophys. Res. Commun. 253 (2): 358–63. December 1998. doi:10.1006/bbrc.1998.9799. PMID 9878542.
- ↑ 13.0 13.1 13.2 13.3 13.4 "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell 9 (3): 611–23. March 2002. doi:10.1016/s1097-2765(02)00468-9. PMID 11931768.
- ↑ 14.0 14.1 14.2 14.3 "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell 12 (3): 723–34. September 2003. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
- ↑ 15.0 15.1 15.2 15.3 "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. March 2003. doi:10.1093/emboj/cdg120. PMID 12628926.
- ↑ "Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735". Mol. Endocrinol. 17 (5): 845–59. May 2003. doi:10.1210/me.2002-0320. PMID 12569182.
- ↑ "RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding". J. Biol. Chem. 277 (29): 26238–43. July 2002. doi:10.1074/jbc.M203268200. PMID 12011091.
- ↑ 18.0 18.1 "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. 276 (38): 35826–35. September 2001. doi:10.1074/jbc.M104935200. PMID 11466315.
- ↑ 19.0 19.1 "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". EMBO J. 19 (16): 4342–50. August 2000. doi:10.1093/emboj/19.16.4342. PMID 10944117.
- ↑ 20.0 20.1 "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol. Cell 9 (1): 45–57. January 2002. doi:10.1016/s1097-2765(01)00429-4. PMID 11804585.
- ↑ 21.0 21.1 "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1". J. Biol. Chem. 275 (51): 40463–70. December 2000. doi:10.1074/jbc.M007864200. PMID 11013263.
- ↑ 22.0 22.1 "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes Dev. 14 (1): 45–54. January 2000. doi:10.1101/gad.14.1.45. PMID 10640275.
- ↑ "The histone deacetylase 9 gene encodes multiple protein isoforms". J. Biol. Chem. 278 (18): 16059–72. May 2003. doi:10.1074/jbc.M212935200. PMID 12590135.
- ↑ "HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling". Mol. Cell. Biol. 21 (17): 6080–9. September 2001. doi:10.1128/mcb.21.17.6080-6089.2001. PMID 11486045.
- ↑ "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein". Cell 110 (1): 55–67. July 2002. doi:10.1016/S0092-8674(02)00809-7. PMID 12150997.
- ↑ "The Ski protein family is required for MeCP2-mediated transcriptional repression". J. Biol. Chem. 276 (36): 34115–21. September 2001. doi:10.1074/jbc.M105747200. PMID 11441023.
- ↑ 27.0 27.1 27.2 "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". J. Biol. Chem. 274 (22): 15901–7. May 1999. doi:10.1074/jbc.274.22.15901. PMID 10336495.
- ↑ "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression". Mol. Cell 7 (6): 1233–43. June 2001. doi:10.1016/s1097-2765(01)00257-x. PMID 11430826.
- ↑ "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol. 21 (19): 6470–83. October 2001. doi:10.1128/mcb.21.19.6470-6483.2001. PMID 11533236.
- ↑ "Oligomerization of ETO is obligatory for corepressor interaction". Mol. Cell. Biol. 21 (1): 156–63. January 2001. doi:10.1128/MCB.21.1.156-163.2001. PMID 11113190.
- ↑ "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood 91 (8): 2634–42. April 1998. doi:10.1182/blood.V91.8.2634.2634_2634_2642. PMID 9531570.
- ↑ "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors". Mol. Cell 2 (1): 33–42. July 1998. doi:10.1016/s1097-2765(00)80111-2. PMID 9702189.
- ↑ "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes Dev. 14 (9): 1048–57. May 2000. doi:10.1101/gad.14.9.1048. PMID 10809664.
External links
- nuclear receptor corepressor 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C97
- Overview of all the structural information available in the PDB for UniProt: O75376 (Nuclear receptor corepressor 1) at the PDBe-KB.
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