Biology:Glutamine—fructose-6-phosphate transaminase (isomerizing)
| glutamine-fructose-6-phosphate transaminase (isomerizing) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Glutamine—fructose-6-phosphate transaminase 1, homodimer, Human | |||||||||
| Identifiers | |||||||||
| EC number | 2.6.1.16 | ||||||||
| CAS number | 9030-45-9 | ||||||||
| Alt. names |
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| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) is an enzyme that catalyzes the chemical reaction
- L-glutamine + D-fructose 6-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] L-glutamate + D-glucosamine 6-phosphate
Thus, the two substrates of this enzyme are L-glutamine and D-fructose 6-phosphate, whereas its two products are L-glutamate and D-glucosamine 6-phosphate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:D-fructose-6-phosphate isomerase (deaminating). This enzyme participates in glutamate metabolism and aminosugars metabolism.
Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1JXA, 1MOQ, 1MOR, 1MOS, 1XFF, 1XFG, 2BPL, 2J6H, 2POC, 2PUT, 2PUV, and 2PUW.
References
- "Glucosamine metabolism. V. Enzymatic synthesis of glucosamine 6-phosphate". J. Biol. Chem. 235: 1265–73. 1960. PMID 13827775.
- "Further studies on glucosamine 6-phosphate synthesis by rat liver enzymes". J. Biol. Chem. 235: 558–62. 1960. PMID 13829889.
- "The biosynthesis of glucosamine". Biochim. Biophys. Acta 12 (1–2): 15–22. 1953. doi:10.1016/0006-3002(53)90119-X. PMID 13115409.
- "The mechanism of sugar phosphate isomerization by glucosamine 6-phosphate synthase". Protein Sci. 8 (3): 596–602. 1999. doi:10.1110/ps.8.3.596. PMID 10091662.
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