Biology:Golph3

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens

Golgi phosphoprotein 3 (GOLPH3) is a human protein encoded by GOLPH3 gene. It is a peripheral membrane protein of the Golgi that probably has a regulatory role in Golgi trafficking. [1]

Clinical significance

Golph 3 expression is associated with poor prognosis of various cancers of gastrointestinal tract, such as gastric and esophageal squamous cell carcinoma.[2][3] Higher expression of GOLPH3 is reported to be associated with greater sensitivity of colorectal cancer to Fluorouracil therapy.[4]

Notes and references

  1. ↑ "Entrez Gene: GOLPH3 golgi phosphoprotein 3". https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=full_report&list_uids=64083. 
  2. ↑ Wang JH (2013). "High Expression of GOLPH3 in Esophageal Squamous Cell Carcinoma Correlates with Poor Prognosis". PLOS ONE 7 (10): e45622. doi:10.1371/journal.pone.0045622. PMID 23056210. Bibcode: 2012PLoSO...745622W. 
  3. ↑ Hu BS (Feb 2013). "Overexpression of GOLPH3 is associated with poor clinical outcome in gastric cancer.". Tumour Biol. 34 (1): 515–20. doi:10.1007/s13277-012-0576-z. PMID 23132295. 
  4. ↑ Wang Z (Jan 2014). "GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy". J. Transl. Med. 12 (1): 15. doi:10.1186/1479-5876-12-15. PMID 24444035. 




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