Biology:Growth factor-like domain
From HandWiki
| Amyloid precursor N-terminal | |||||||||||
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 The GFLD region of amyloid precursor protein | |||||||||||
| Identifiers | |||||||||||
| Symbol | APP_CU_bd | ||||||||||
| Pfam | PF02177 | ||||||||||
| InterPro | IPR008154 | ||||||||||
| SMART | SM00006 | ||||||||||
| SCOP2 | 1mwp / SCOPe / SUPFAM | ||||||||||
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A growth factor-like domain (GFLD) is a protein domain structurally related to epidermal growth factor, which has a high binding affinity for the epidermal growth factor receptor. As structural domains within larger proteins, GFLD regions commonly bind calcium ions. A subtype present in the N-terminal region of the amyloid precursor protein is a member of the heparin-binding class of GFLDs and may itself have growth factor function, particularly in promoting neuronal development.
References
- "Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein". Nature Structural Biology 6 (4): 327–31. April 1999. doi:10.1038/7562. PMID 10201399.
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