Biology:HIPK1
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Homeodomain-interacting protein kinase 1 is an enzyme that in humans is encoded by the HIPK1 gene.[1]
Function
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.[1]
Interactions
HIPK1 has been shown to interact with P53.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: HIPK1 homeodomain interacting protein kinase 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=204851.
- ↑ "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)". Proceedings of the National Academy of Sciences of the United States of America 100 (9): 5431–6. Apr 2003. doi:10.1073/pnas.0530308100. PMID 12702766. Bibcode: 2003PNAS..100.5431K.
Further reading
- "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 5 (3): 169–76. Jun 1998. doi:10.1093/dnares/5.3.169. PMID 9734811.
- "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors". The Journal of Biological Chemistry 273 (40): 25875–9. Oct 1998. doi:10.1074/jbc.273.40.25875. PMID 9748262.
- "Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity". Molecular and Cellular Biology 23 (3): 950–60. Feb 2003. doi:10.1128/MCB.23.3.950-960.2003. PMID 12529400.
- "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)". Proceedings of the National Academy of Sciences of the United States of America 100 (9): 5431–6. Apr 2003. doi:10.1073/pnas.0530308100. PMID 12702766. Bibcode: 2003PNAS..100.5431K.
- "Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization". The Journal of Biological Chemistry 278 (47): 47245–52. Nov 2003. doi:10.1074/jbc.M213201200. PMID 12968034.
- "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. Jul 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation". The Journal of Biological Chemistry 280 (15): 15061–70. Apr 2005. doi:10.1074/jbc.M414262200. PMID 15701637.
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