Biology:HLA-DR10
From HandWiki
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major histocompatibility complex, class II, DR10
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| Haplotypes groups | DQA*01:DRB1*1001 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101
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| Symbol(s) | HLA-DRA[yes|permanent dead link|dead link}}] |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *1001
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| Symbol(s) | HLA-DRB1[yes|permanent dead link|dead link}}] |
| EBI-HLA | DRB1*1001 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.
Serology
| DRB1* | DR10 | DR1 | Sample | |
| allele | % | % | % | size (N) |
| 1001 | 90 | 4 | 894 |
The serological reaction of DR10 is relatively good.
Disease associations
By serotype
DR10 serotype or cognate alleles are associated with: Lichen planus[2]
By allele
DRB1*1001 is associated with ovarian cancer[3] and invasive squamous cell cervical cancer (SCC)[4]
Extended linkage
DRB1*1001:DQA1*01:DQB1*05 haplotype: Rheumatoid arthritis[5] The primary involvement appears to be DR10.
Genetic Linkage
DR10 Haplotypes
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| DRA | DRB1 | ||
|---|---|---|---|
| Haplotypes | *0101 | *1001 | |
| DQA1 | DQB1 | DRB1 | |
| Haplotypes | *0101 | *0501 | *1001 |
| HLA-A | HLA-B | DRB1 | |
| Haplotypes | *0000 | *0000 | *1001 |
HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. One haplotype found in caucasians is the HLA-A1-B37-Cw6-DR10-DQ5.
References
- ↑ derived from IMGT/HLA
- ↑ "HLA antigens in Arabs with lichen planus.". Clinical and Experimental Dermatology 19 (3): 236–7. 1994. doi:10.1111/j.1365-2230.1994.tb01174.x. PMID 8033385.
- ↑ "HLA-class II haplotype associations with ovarian cancer.". Int J Cancer 119 (12): 2980–5. 2006. doi:10.1002/ijc.22266. PMID 17016821.
- ↑ "Human leukocyte antigen class II and cervical cancer risk: a population-based study.". J Infect Dis 186 (11): 1565–74. 2002. doi:10.1086/345285. PMID 12447731.
- ↑ "Rheumatoid arthritis in southern Spain: toward elucidation of a unifying role of the HLA class II region in disease predisposition.". Arthritis Rheum 44 (2): 307–14. 2001. doi:10.1002/1529-0131(200102)44:2<307::AID-ANR47>3.0.CO;2-K. PMID 11229460.
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