Biology:HULC (gene)
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In molecular biology, Highly Up-regulated in Liver Cancer (non-protein coding), also known as HULC, is a long non-coding RNA. It was first identified in hepatocellular carcinoma, and is also expressed in colorectal carcinomas that metastasise to the liver.[1][2] It may have a role in the post-transcriptional regulation of gene expression.[1] It downregulates the expression of several microRNAs, including miR-372.[3] Expression of HULC is upregulated by CREB, there is a CREB-binding site in the promoter of HULC. miR-372 represses translation of the kinase PRKACB, so downregulation of miR-372 leads to increased levels of PRKACB. PRKACB activates CREB by phosphorylation, therefore leading to increased expression of HULC.[3]
See also
- Long noncoding RNA
References
- ↑ 1.0 1.1 "Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA". Gastroenterology 132 (1): 330–342. Jan 2007. doi:10.1053/j.gastro.2006.08.026. PMID 17241883.
- ↑ "Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis". European Journal of Gastroenterology & Hepatology 21 (6): 688–692. Jun 2009. doi:10.1097/meg.0b013e328306a3a2. PMID 19445043.
- ↑ 3.0 3.1 "CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer". Nucleic Acids Research 38 (16): 5366–5383. Sep 2010. doi:10.1093/nar/gkq285. PMID 20423907.
Further reading
- "[Specifically up-regulated non-coding RNA gene HULC in tumor cell lines and its effects on the expression of neighboring gene SLC35B3]". Zhonghua Yi Xue Za Zhi 90 (44): 3156–3159. Nov 2010. PMID 21211351.
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