Biology:Helicase–primase complex
From HandWiki
A helicase–primase complex (also helicase-primase, Hel/Prim, H-P or H/P) is a complex of enzymes including DNA helicase and DNA primase. A helicase-primase associated factor protein may also be present.[1]
The complex is used by herpesviruses, in which it is responsible for lytic DNA virus replication.[2][3][4] In many dsDNA viruses, primase and helicase are fused into a single polypeptide chain, so that the primase and helicase domains correspond to the N-terminal and C-terminal parts of the protein, respectively.[5] A helicase-primase inhibitor (HPI) is a drug that blocks this action through acting as an enzyme inhibitor.
List of H-P by virus name
- EBV: helicase:BBLF4 primase: BSLF1 accessory protein:BBLF2/3[2]
List of H-P inhibitors
- Amenamevir (ASP2151)[6]
- Pritelivir (BAY 57–1293, AIC316)
- BILS 22 BS[6]
- T157602[6]
References
- ↑ Encyclopedia of toxicology (2nd ed.). Academic Press. 2005. p. 1850. ISBN 978-0-08-054800-5. https://books.google.com/books?id=uQEkJw00eqcC&q=Encyclopedia+of+Toxicology+A+helicase-primase+associated+factor+protein&pg=PT1850.
- ↑ 2.0 2.1 "Production and characterisation of Epstein-Barr virus helicase-primase complex and its accessory protein BBLF2/3". Virus Genes 51 (2): 171–81. October 2015. doi:10.1007/s11262-015-1233-6. PMID 26292944.
- ↑ Kräusslich, Hans-Georg; Bartenschlager, Ralf (2 December 2008). Antiviral Strategies. Springer Science & Business Media. pp. 162–8. ISBN 978-3-540-79086-0. https://books.google.com/books?id=r_Dq0xIZ7d&pg=PA162.
- ↑ Cavanaugh, Nisha Angele (2008). Herpes DNA Synthesis: Initiation of New DNA Strands and Discrimination Between Right and Wrong Bases by the Polymerase (Ph.D.). University of Colorado at Boulder. pp. 2–12. ISBN 978-0-549-67366-8.
- ↑ "The logic of DNA replication in double-stranded DNA viruses: insights from global analysis of viral genomes". Nucleic Acids Research 44 (10): 4551–64. June 2016. doi:10.1093/nar/gkw322. PMID 27112572.
- ↑ 6.0 6.1 6.2 "The DNA helicase-primase complex as a target for herpes viral infection". Expert Opinion on Therapeutic Targets 17 (10): 1119–32. October 2013. doi:10.1517/14728222.2013.827663. PMID 23930666.
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