Chemistry:Tromantadine
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Short description: Antiviral medicine used to treat herpes simplex virus
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| Trade names | Viru-Merz |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Topical (gel) |
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| Formula | C16H28N2O2 |
| Molar mass | 280.412 g·mol−1 |
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Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade names Viru-Merz and Viru-Merz Serol. Its performance is similar to aciclovir.[1][2]
Like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane.
Mechanism
Tromantadine inhibits the early and late events in the virus replication cycle.[3] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.[citation needed]
References
- ↑ "Randomized double-blind trial of tromantadine versus aciclovir in recurrent herpes orofacialis". Arzneimittel-Forschung 39 (9): 1152–1155. September 1989. PMID 2686658.
- ↑ "Efficacy of tromantadine and aciclovir in the topical treatment of recurrent herpes orofacialis. Comparison in a clinical trial". Arzneimittel-Forschung 43 (4): 491–496. April 1993. PMID 8494582.
- ↑ "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrobial Agents and Chemotherapy 22 (6): 1031–1036. December 1982. doi:10.1128/aac.22.6.1031. PMID 6297383.
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