Biology:Hypotaurine dehydrogenase
From HandWiki
| hypotaurine dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.8.1.3 | ||||||||
| CAS number | 37256-46-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a hypotaurine dehydrogenase (EC 1.8.1.3) is an enzyme that catalyzes the chemical reaction
- hypotaurine + H2O + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] taurine + NADH + H+
The 3 substrates of this enzyme are hypotaurine, H2O, and NAD+, whereas its 3 products are taurine, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hypotaurine:NAD+ oxidoreductase. This enzyme participates in taurine and hypotaurine metabolism. It has 2 cofactors: heme, and Molybdenum.
References
- "Oxidation of hypotaurine in rat liver". Biochimica et Biophysica Acta 63: 210–2. September 1962. doi:10.1016/0006-3002(62)90357-8. PMID 13979247.
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