Biology:Iron-sulfur cluster biosynthesis protein family
In molecular biology, the iron-sulfur cluster biosynthesis protein family of includes proteins involved in biogenesis of Fe-S clusters (iron-sulfur cluster insertion protein, Fe/S biogenesis protein). This family includes IscA, HesB, YadR and YfhF-like proteins. The hesB gene is expressed only under nitrogen fixation conditions, within nitrogen fixing cyanobacteria.[1] IscA, an 11 kDa member of the hesB family of proteins, binds iron and [2Fe-2S] clusters, and participates in the biosynthesis of iron-sulfur proteins. IscA is able to bind at least 2 iron ions per dimer.[2] Other members of this family include various hypothetical proteins that also contain the NifU-like domain suggesting that they too are able to bind iron and are involved in Fe-S cluster biogenesis. The HesB family are found in species as divergent as Homo sapiens (Human) and Haemophilus influenzae suggesting that these proteins are involved in basic cellular functions.[3]
References
- ↑ "Organization and expression of nitrogen-fixation genes in the aerobic nitrogen-fixing unicellular cyanobacterium Synechococcus sp. strain RF-1". Microbiology 145 (3): 743–53. March 1999. doi:10.1099/13500872-145-3-743. PMID 10217509.
- ↑ "Crystal structure of IscA, an iron-sulfur cluster assembly protein from Escherichia coli". J. Mol. Biol. 338 (1): 127–37. April 2004. doi:10.1016/j.jmb.2004.02.027. PMID 15050828.
- ↑ "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution". J. Mol. Evol. 43 (5): 536–40. November 1996. doi:10.1007/BF02337525. PMID 8875867. Bibcode: 1996JMolE..43..536H.
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