Biology:Kynurenine—glyoxylate transaminase
| Kynurenine-glyoxylate transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.6.1.63 | ||||||||
| CAS number | 74506-33-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Kynurenine-glyoxylate transaminase (EC 2.6.1.63) is an enzyme that catalyzes the overall chemical reaction:
- REDIRECT Template:Chemical reaction
The two substrates of this enzyme characterised from liver are L-kynurenine and glyoxylic acid. The amino group from the amino acid of kynurenine is transferred, forming glycine and an intermediate α-keto acid, which spontaneously loses water to give kynurenic acid as the stable product.[1] The enzyme accepts other substrates, including alanine and 3-hydroxykynurenine. It is found in Aedes aegypti and Anopheles gambiae.[2][3]
This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is L-kynurenine:glyoxylate aminotransferase (cyclizing). This enzyme is also called kynurenine-glyoxylate aminotransferase.[4]
References
- ↑ Harada, Izumi; Noguchi, Tomoo; Kido, Ryo (1978). "Purification and Characterization of Aromatic-Amino-Acid-Glyoxylate Aminotransferase from Monkey and Rat Liver". Biological Chemistry 359 (4): 481–488. doi:10.1515/bchm.1978.359.1.481. PMID 25837.
- ↑ Han, Qian; Fang, Jianmin; Li, Jianyong (2002). "3-Hydroxykynurenine Transaminase Identity with Alanine Glyoxylate Transaminase". Journal of Biological Chemistry 277 (18): 15781–15787. doi:10.1074/jbc.M201202200. PMID 11880382.
- ↑ Rossi, Franca; Lombardo, Fabrizio; Paglino, Alessandra; Cassani, Camilla; Miglio, Gianluca; Arcà, Bruno; Rizzi, Menico (2005). "Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase". The FEBS Journal 272 (21): 5653–5662. doi:10.1111/j.1742-4658.2005.04961.x. PMID 16262702.
- ↑ Enzyme 2.6.1.63 at KEGG Pathway Database.
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