Biology:MAP3K14
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme that in humans is encoded by the MAP3K14 gene.[1][2]
Function
This gene encodes mitogen-activated protein kinase kinase kinase 14, NIK, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-κB activity. It is a critical kinase of the alternative NF-κB activation pathway. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.[2]
Interactions
MAP3K14 has been shown to interact with:
References
- ↑ 1.0 1.1 "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1". Nature 385 (6616): 540–4. March 1997. doi:10.1038/385540a0. PMID 9020361.
- ↑ 2.0 2.1 "Entrez Gene: MAP3K14 mitogen-activated protein ki kinase kinase 14". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9020.
- ↑ 3.0 3.1 3.2 "Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602–6. May 2001. doi:10.1074/jbc.C100103200. PMID 11278268.
- ↑ "Identification and characterization of an IkappaB kinase". Cell 90 (2): 373–83. July 1997. doi:10.1016/S0092-8674(00)80344-X. PMID 9244310.
- ↑ "Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain". J. Biol. Chem. 275 (28): 21081–5. July 2000. doi:10.1074/jbc.M002552200. PMID 10887201.
- ↑ "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature 398 (6724): 252–6. March 1999. doi:10.1038/18465. PMID 10094049. Bibcode: 1999Natur.398..252N.
- ↑ "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK". Science 278 (5339): 866–9. October 1997. doi:10.1126/science.278.5339.866. PMID 9346485. Bibcode: 1997Sci...278..866W.
Further reading
- "Identification and characterization of an IkappaB kinase". Cell 90 (2): 373–83. 1997. doi:10.1016/S0092-8674(00)80344-X. PMID 9244310.
- "Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9792–6. 1997. doi:10.1073/pnas.94.18.9792. PMID 9275204. Bibcode: 1997PNAS...94.9792S.
- "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK". Science 278 (5339): 866–9. 1997. doi:10.1126/science.278.5339.866. PMID 9346485. Bibcode: 1997Sci...278..866W.
- "NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3792–7. 1998. doi:10.1073/pnas.95.7.3792. PMID 9520446. Bibcode: 1998PNAS...95.3792L.
- "MEKK1 activates both IκB kinase α and IκB kinase β". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9319–24. 1998. doi:10.1073/pnas.95.16.9319. PMID 9689078. Bibcode: 1998PNAS...95.9319L.
- "Molecular Determinants of NF-κB-Inducing Kinase Action". Mol. Cell. Biol. 18 (10): 5899–907. 1998. doi:10.1128/mcb.18.10.5899. PMID 9742107.
- "IKAP is a scaffold protein of the IkappaB kinase complex". Nature 395 (6699): 292–6. 1998. doi:10.1038/26254. PMID 9751059. Bibcode: 1998Natur.395..292C.
- "The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17". Hum. Genet. 103 (3): 340–5. 1998. doi:10.1007/s004390050827. PMID 9799091.
- "Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase". Mol. Cell. Biol. 18 (12): 7336–43. 1998. doi:10.1128/mcb.18.12.7336. PMID 9819420.
- "Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis". Proc. Natl. Acad. Sci. U.S.A. 96 (3): 1042–7. 1999. doi:10.1073/pnas.96.3.1042. PMID 9927690. Bibcode: 1999PNAS...96.1042L.
- "Activation of IκB Kinase β by Protein Kinase C Isoforms". Mol. Cell. Biol. 19 (3): 2180–8. 1999. doi:10.1128/MCB.19.3.2180. PMID 10022904.
- "The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases". Immunity 10 (2): 271–80. 1999. doi:10.1016/S1074-7613(00)80027-8. PMID 10072079.
- "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature 398 (6724): 252–6. 1999. doi:10.1038/18465. PMID 10094049. Bibcode: 1999Natur.398..252N.
- "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation". Science 284 (5412): 309–13. 1999. doi:10.1126/science.284.5412.309. PMID 10195894.
- "Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways". J. Biol. Chem. 274 (43): 30603–10. 1999. doi:10.1074/jbc.274.43.30603. PMID 10521444.
- "IκB Kinase α (IKKα) Regulation of IKKβ Kinase Activity". Mol. Cell. Biol. 20 (10): 3655–66. 2000. doi:10.1128/MCB.20.10.3655-3666.2000. PMID 10779355.
- "Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain". J. Biol. Chem. 275 (28): 21081–5. 2000. doi:10.1074/jbc.M002552200. PMID 10887201.
- "Activation of the NF-kappaB pathway by caspase 8 and its homologs". Oncogene 19 (39): 4451–60. 2000. doi:10.1038/sj.onc.1203812. PMID 11002417.
- "The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A". J. Biol. Chem. 276 (4): 2668–77. 2001. doi:10.1074/jbc.M008356200. PMID 11035039.
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