Biology:Interleukin 1 receptor, type I
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Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.[1]
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.[1]
Interactions
Interleukin 1 receptor, type I has been shown to interact with PIK3R1,[2] Myd88[3][4] and IL1RAP.[5]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: IL1R1 interleukin 1 receptor, type I". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3554.
- ↑ Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. (UNITED STATES) 272 (46): 29167–73. doi:10.1074/jbc.272.46.29167. ISSN 0021-9258. PMID 9360994.
- ↑ Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K et al. (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. (ENGLAND) 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325.
- ↑ Muzio, M; Ni J; Feng P; Dixit V M (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science (UNITED STATES) 278 (5343): 1612–5. doi:10.1126/science.278.5343.1612. ISSN 0036-8075. PMID 9374458. Bibcode: 1997Sci...278.1612M.
- ↑ Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (24): 12829–32. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMID 9371760. Bibcode: 1997PNAS...9412829H.
Further reading
- "Chromosomal location of murine and human IL-1 receptor genes.". Genomics 9 (1): 44–50. 1991. doi:10.1016/0888-7543(91)90219-5. PMID 1672292.
- "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.". EMBO J. 10 (10): 2821–32. 1991. doi:10.1002/j.1460-2075.1991.tb07831.x. PMID 1833184.
- "Identification of IL-1 receptors on human monocytes.". J. Immunol. 142 (5): 1576–81. 1989. PMID 2521881.
- "Cloning the interleukin 1 receptor from human T cells.". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8946–50. 1989. doi:10.1073/pnas.86.22.8946. PMID 2530587. Bibcode: 1989PNAS...86.8946S.
- "Sequence of the cDNA for the human fibroblast type interleukin-1 receptor.". Nucleic Acids Res. 17 (23): 10114. 1990. doi:10.1093/nar/17.23.10114. PMID 2532321.
- "The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical.". Nature 324 (6094): 266–8. 1987. doi:10.1038/324266a0. PMID 2946959. Bibcode: 1986Natur.324..266D.
- "HIV-1 Tat induces cytokine synthesis by uninfected mononuclear cells.". AIDS 8 (10): 1504–6. 1995. doi:10.1097/00002030-199410000-00023. PMID 7818827.
- "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190–4. 1997. doi:10.1038/386190a0. PMID 9062193. Bibcode: 1997Natur.386..190V.
- "A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist.". Nature 386 (6621): 194–200. 1997. doi:10.1038/386194a0. PMID 9062194. Bibcode: 1997Natur.386..194S.
- "Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts.". J. Immunol. 158 (7): 3417–24. 1997. PMID 9120302.
- "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation.". J. Biol. Chem. 272 (46): 29167–73. 1997. doi:10.1074/jbc.272.46.29167. PMID 9360994.
- "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. 1998. doi:10.1073/pnas.94.24.12829. PMID 9371760. Bibcode: 1997PNAS...9412829H.
- "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.". Science 278 (5343): 1612–5. 1997. doi:10.1126/science.278.5343.1612. PMID 9374458. Bibcode: 1997Sci...278.1612M.
- "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177–9. 1999. doi:10.1006/geno.1999.5767. PMID 10191101.
- "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit.". Mol. Cell. Biol. 19 (7): 4798–805. 1999. doi:10.1128/mcb.19.7.4798. PMID 10373529.
- "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.". Nat. Cell Biol. 2 (6): 346–51. 2000. doi:10.1038/35014038. PMID 10854325.
- "X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1.". J. Biol. Chem. 275 (47): 36927–33. 2001. doi:10.1074/jbc.M006071200. PMID 10903327.
- "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member.". J. Biol. Chem. 276 (23): 20597–602. 2001. doi:10.1074/jbc.M010095200. PMID 11278614.
- "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863–6. 2001. doi:10.1136/thorax.56.11.863. PMID 11641511.
- "Influence of low molecular weight heparin (certoparin) and unfractionated heparin on the release of cytokines from human leukocytes.". Inflammation 25 (5): 331–7. 2003. doi:10.1023/A:1012883916991. PMID 11820460.
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External links
- IL1R1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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