Biology:MARK3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.

Interactions

MARK3 has been shown to interact with Stratifin.

It has been linked to a form of genetic blindness, believed to be a genetic recessive disease that progressively destroys the eyes.

Further reading

• "An overview of the KIN1/PAR-1/MARK kinase family.". Biol. Cell 96 (3): 193–9. 2004. doi:10.1016/j.biolcel.2003.10.009. PMID 15182702. 
• "Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function.". Mol. Cell. Biol. 16 (10): 5782–91. 1996. doi:10.1128/MCB.16.10.5782. PMID 8816492. 
• "C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.". Cell Growth Differ. 9 (3): 197–208. 1998. PMID 9543386. 
• "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.". Nat. Cell Biol. 3 (7): 628–36. 2001. doi:10.1038/35083016. PMID 11433294. 
• "Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.". Oncogene 22 (30): 4752–6. 2003. doi:10.1038/sj.onc.1206669. PMID 12879020. 
• "Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.". EMBO J. 22 (17): 4431–42. 2003. doi:10.1093/emboj/cdg426. PMID 12941695. 
• "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.". J. Biol. Chem. 279 (7): 5915–23. 2004. doi:10.1074/jbc.M304528200. PMID 14594945. 
• "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics 4 (2): 339–46. 2004. doi:10.1002/pmic.200300528. PMID 14760703. 
• "The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint.". J. Biol. Chem. 279 (46): 48319–28. 2005. doi:10.1074/jbc.M404440200. PMID 15319445. 
• "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell. Proteomics 4 (6): 785–95. 2005. doi:10.1074/mcp.M500021-MCP200. PMID 15778465. 
• "A human protein–protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• "Towards a proteome-scale map of the human protein–protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation.". J. Cell Sci. 119 (Pt 19): 4059–70. 2007. doi:10.1242/jcs.03097. PMID 16968750. 
• "New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.". Mol. Cell. Biol. 26 (19): 7086–102. 2006. doi:10.1128/MCB.00231-06. PMID 16980613. PMC 1592903. http://orbi.ulg.ac.be/bitstream/2268/32348/1/Dequiedt%20et%20al%202006.pdf. 
• "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell. Proteomics 6 (3): 537–47. 2007. doi:10.1074/mcp.T600062-MCP200. PMID 17192257. 
• "Large-scale mapping of human protein–protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.