Biology:MED25
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.[1][2][3]
Intellectual developmental disorder
A homozygous variant in the MED25 gene, leading to an arginine to trypsin substitution, was identified in seven individuals with impaired intellectual development and characteristic facial features.[4] The genetic variant segregated with the disorder and was not found in control populations. This putative homozygous variant arose 218 years ago in this Brazilian family.[5]
Interactions
MED25 has been shown to interact with MED4.[6]
References
- ↑ "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. Apr 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- ↑ "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- ↑ "Entrez Gene: MED25 mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=81857.
- ↑ Figueiredo, Thalita; Melo, Uirá Souto; Pessoa, André Luiz Santos; Nobrega, Paulo Ribeiro; Kitajima, João Paulo; Correa, Igor; Zatz, Mayana; Kok, Fernando et al. (February 2015). "Homozygous missense mutation in MED25 segregates with syndromic intellectual disability in a large consanguineous family". Journal of Medical Genetics 52 (2): 123–127. doi:10.1136/jmedgenet-2014-102793. PMID 25527630.
- ↑ de Farias, Allysson Allan; Nunes, Kelly; Lemes, Renan Barbosa; Moura, Ronald; Fernandes, Gustavo Ribeiro; Melo, Uirá Souto; Zatz, Mayana; Kok, Fernando et al. (8 November 2018). "Origin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations". Scientific Reports 8 (1). doi:10.1038/s41598-018-35022-1. PMID 30410084. Bibcode: 2018NatSR...816552D.
- ↑ "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry 279 (7): 5846–51. Feb 2004. doi:10.1074/jbc.M312523200. PMID 14638676. https://authors.library.caltech.edu/records/7e4h4-sxm34/files/TOMjbc04.pdf?download=1.
Further reading
- "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature 398 (6730): 828–32. Apr 1999. doi:10.1038/19789. PMID 10235267. Bibcode: 1999Natur.398..828N.
- "A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein". Biochemical and Biophysical Research Communications 296 (2): 281–7. Aug 2002. doi:10.1016/S0006-291X(02)00872-0. PMID 12163014. Bibcode: 2002BBRC..296..281W.
- "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry 278 (50): 49671–4. Dec 2003. doi:10.1074/jbc.C300444200. PMID 14576168. https://authors.library.caltech.edu/records/s8gdw-2nv54/files/SATjbc03a.pdf?download=1.
- "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry 279 (7): 5846–51. Feb 2004. doi:10.1074/jbc.M312523200. PMID 14638676. https://authors.library.caltech.edu/records/7e4h4-sxm34/files/TOMjbc04.pdf?download=1.
- "A novel docking site on Mediator is critical for activation by VP16 in mammalian cells". The EMBO Journal 22 (24): 6494–504. Dec 2003. doi:10.1093/emboj/cdg619. PMID 14657022.
- "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proceedings of the National Academy of Sciences of the United States of America 101 (8): 2339–44. Feb 2004. doi:10.1073/pnas.0308676100. PMID 14983011. Bibcode: 2004PNAS..101.2339Y.
- "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell 14 (5): 685–91. Jun 2004. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- "MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription". Molecular Cell 19 (1): 89–100. Jul 2005. doi:10.1016/j.molcel.2005.05.015. PMID 15989967.
- "MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation". The EMBO Journal 26 (15): 3545–57. Aug 2007. doi:10.1038/sj.emboj.7601797. PMID 17641689.
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