Biology:MED6
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
| Med6 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Med6 | ||||||||
| Pfam | PF04934 | ||||||||
| InterPro | IPR007018 | ||||||||
| |||||||||
Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.[1][2][3]
Protein family
This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans.[1]
Interactions
MED6 has been shown to interact with:
- Cyclin-dependent kinase 8,[4][5][6][7]
- Estrogen receptor alpha,[7]
- MED21,[8] and
- Thyroid hormone receptor alpha.[6]
References
- ↑ 1.0 1.1 "A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans". Mol. Cell. Biol. 17 (8): 4622–32. August 1997. doi:10.1128/MCB.17.8.4622. PMID 9234719.
- ↑ "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc Natl Acad Sci U S A 95 (15): 8538–8543. Aug 1998. doi:10.1073/pnas.95.15.8538. PMID 9671713. Bibcode: 1998PNAS...95.8538J.
- ↑ "Entrez Gene: MED6 mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10001.
- ↑ "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2339–44. Feb 2004. doi:10.1073/pnas.0308676100. PMID 14983011. Bibcode: 2004PNAS..101.2339Y.
- ↑ "Characterization of mediator complexes from HeLa cell nuclear extract". Mol. Cell. Biol. 21 (14): 4604–13. Jul 2001. doi:10.1128/MCB.21.14.4604-4613.2001. PMID 11416138.
- ↑ 6.0 6.1 "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell 3 (3): 361–70. Mar 1999. doi:10.1016/s1097-2765(00)80463-3. PMID 10198638.
- ↑ 7.0 7.1 "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. Mar 2002. doi:10.1073/pnas.261715899. PMID 11867769. Bibcode: 2002PNAS...99.2642K.
- ↑ "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell 2 (2): 213–22. Aug 1998. doi:10.1016/s1097-2765(00)80131-8. PMID 9734358.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell 2 (2): 213–222. 1998. doi:10.1016/S1097-2765(00)80131-8. PMID 9734358.
- "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell 3 (1): 97–108. 1999. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
- "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell 3 (3): 361–370. 1999. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
- "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature 398 (6730): 824–828. 1999. doi:10.1038/19783. PMID 10235266. Bibcode: 1999Natur.398..824R.
- "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature 398 (6730): 828–832. 1999. doi:10.1038/19789. PMID 10235267. Bibcode: 1999Natur.398..828N.
- "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–464. 1999. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature 417 (6888): 563–567. 2002. doi:10.1038/417563a. PMID 12037571. Bibcode: 2002Natur.417..563G.
- "A component of the ARC/Mediator complex required for TGF beta/Nodal signalling". Nature 418 (6898): 641–646. 2002. doi:10.1038/nature00969. PMID 12167862. Bibcode: 2002Natur.418..641K.
- "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–15127. 2003. doi:10.1074/jbc.C300054200. PMID 12584197.
- "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–49674. 2004. doi:10.1074/jbc.C300444200. PMID 14576168.
- "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–5851. 2004. doi:10.1074/jbc.M312523200. PMID 14638676.
- "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2339–2344. 2004. doi:10.1073/pnas.0308676100. PMID 14983011. Bibcode: 2004PNAS..101.2339Y.
- "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell 14 (5): 685–691. 2004. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- "PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator". Mol. Cell 18 (1): 83–96. 2005. doi:10.1016/j.molcel.2005.02.034. PMID 15808511.
External links
- MED6 human gene location in the UCSC Genome Browser.
- MED6 human gene details in the UCSC Genome Browser.
 |  |
