Biology:MFGE8
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Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein that in humans is encoded by the MFGE8 gene.[1][2]
Species distribution
Mfge8 is a secreted protein found in vertebrates, including mammals as well as birds.
Function
MFGE8 may function as a cell adhesion protein to connect smooth muscle to elastic fibers in arteries.[3] An amyloid fragment of MFGE8 known as medin accumulates in the aorta with aging.[4] MFGE8 in the vasculature of adults can induce recovery from ischemia by facilitating angiogenesis.[5] It has been suggested that antagonizing MFGE8-induced angiogenesis could be a way of fighting cancer.[6]
MFGE8 contains a phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enables the binding to integrins. MFGE8 binds PS, which is exposed on the surface of apoptotic cells.[7] Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell.
References
- ↑ "Entrez Gene: MFGE8 milk fat globule-EGF factor 8 protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4240.
- ↑ "Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25". Genomics 39 (1): 117–8. January 1997. doi:10.1006/geno.1996.4425. PMID 9027496.
- ↑ "Lactadherin binds to elastin--a starting point for medin amyloid formation?". Amyloid 13 (2): 78–85. June 2006. doi:10.1080/13506120600722530. PMID 16911961.
- ↑ "Medin-amyloid: a recently characterized age-associated arterial amyloid form affects mainly arteries in the upper part of the body". Amyloid 12 (2): 96–102. June 2005. doi:10.1080/13506120500107006. PMID 16011985.
- ↑ "Lactadherin promotes VEGF-dependent neovascularization". Nat. Med. 11 (5): 499–506. May 2005. doi:10.1038/nm1233. PMID 15834428.
- ↑ "SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions". J. Cell. Biochem. 106 (6): 957–66. April 2009. doi:10.1002/jcb.22076. PMID 19204935.
- ↑ "Follicular dendritic cells: origin, phenotype, and function in health and disease". Trends in Immunology 35 (3): 105–113. 2014. doi:10.1016/j.it.2013.11.001. PMID 24315719.
Further reading
- "Structural and functional aspects of three major glycoproteins of the human milk fat globule membrane.". Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 501: 179–87. 2002. doi:10.1007/978-1-4615-1371-1_23. ISBN 978-1-4613-5521-2. PMID 11787681.
- "A Mr 46,000 human milk fat globule protein that is highly expressed in human breast tumors contains factor VIII-like domains.". Cancer Res. 51 (18): 4994–8. 1991. PMID 1909932.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an epidermal growth factor-like domain.". DNA Cell Biol. 15 (4): 281–6. 1996. doi:10.1089/dna.1996.15.281. PMID 8639264.
- "Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25.". Genomics 39 (1): 117–8. 1997. doi:10.1006/geno.1996.4425. PMID 9027496.
- "Stage specific expression of milk fat globule membrane glycoproteins in mouse mammary gland: comparison of MFG-E8, butyrophilin, and CD36 with a major milk protein, beta-casein.". Biochim. Biophys. Acta 1334 (2–3): 182–90. 1997. doi:10.1016/s0304-4165(96)00091-8. PMID 9101712.
- "Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion.". DNA Cell Biol. 16 (7): 861–9. 1997. doi:10.1089/dna.1997.16.861. PMID 9260929.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Isolation and characterization of full and truncated forms of human breast carcinoma protein BA46 from human milk fat globule membranes.". J. Protein Chem. 17 (2): 143–8. 1998. doi:10.1023/A:1022531500370. PMID 9535276.
- "Role of human-milk lactadherin in protection against symptomatic rotavirus infection.". Lancet 351 (9110): 1160–4. 1998. doi:10.1016/S0140-6736(97)10322-1. PMID 9643686.
- "Milk fat globule glycoproteins in human milk and in gastric aspirates of mother's milk-fed preterm infants.". Pediatr. Res. 44 (4): 499–506. 1998. doi:10.1203/00006450-199810000-00006. PMID 9773837.
- "Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid.". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8669–74. 1999. doi:10.1073/pnas.96.15.8669. PMID 10411933. Bibcode: 1999PNAS...96.8669H.
- "Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles.". Eur. J. Biochem. 269 (4): 1209–18. 2002. doi:10.1046/j.1432-1033.2002.02758.x. PMID 11856354.
- "Identification of a factor that links apoptotic cells to phagocytes.". Nature 417 (6885): 182–7. 2002. doi:10.1038/417182a. PMID 12000961. Bibcode: 2002Natur.417..182H.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Increased expression of O-acetyl disialoganglioside synthase during rat liver fibrogenesis relates to stellate cell activation.". Biochem. Biophys. Res. Commun. 303 (3): 954–61. 2003. doi:10.1016/S0006-291X(03)00448-0. PMID 12670504.
- "Human myometrial adaptation to pregnancy: cDNA microarray gene expression profiling of myometrium from non-pregnant and pregnant women.". Mol. Hum. Reprod. 9 (11): 681–700. 2004. doi:10.1093/molehr/gag078. PMID 14561811.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Amyloidogenic hexapeptide fragment of medin: homology to functional islet amyloid polypeptide fragments.". Amyloid 11 (2): 81–9. 2005. doi:10.1080/13506120412331272287. PMID 15478463.
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