Biology:MIR187
 Generic protein structure example |
MicroRNA 187 is a protein that in humans is encoded by the MIR187 gene.[1]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA.
References
Further reading
- "IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes". Proceedings of the National Academy of Sciences of the United States of America 109 (45): E3101-10. November 2012. doi:10.1073/pnas.1209100109. PMID 23071313. PMC 3494907. https://air.unimi.it/bitstream/2434/252105/2/pnas.201209100.pdf.
- "Vertebrate microRNA genes". Science 299 (5612): 1540. March 2003. doi:10.1126/science.1080372. PMID 12624257.
- "Numerous microRNPs in neuronal cells containing novel microRNAs". RNA 9 (2): 180–6. February 2003. doi:10.1261/rna.2141503. PMID 12554860.
- "Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2". Oncogene 31 (6): 764–75. February 2012. doi:10.1038/onc.2011.269. PMID 21725366.
- "miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro". Clinical Cancer Research 18 (24): 6702–13. December 2012. doi:10.1158/1078-0432.CCR-12-1420. PMID 23060431.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
