Biology:MIR7-1

Short description: Non-coding RNA in the species Homo sapiens

Generic protein structure example

MicroRNA 7-1 is a microRNA molecule that in humans is encoded by the MIR7-1 gene.

Function

microRNAs, or miRNAs, are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Further reading

• "Vertebrate microRNA genes". Science 299 (5612): 1540. March 2003. doi:10.1126/science.1080372. PMID 12624257. 
• "MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas". Gene Expression Patterns 9 (4): 193–9. April 2009. doi:10.1016/j.gep.2008.12.003. PMID 19135553. 
• Horwitz, Marshall S, ed (September 2011). "Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility". PLOS Genetics 7 (9): e1002259. doi:10.1371/journal.pgen.1002259. PMID 21912531. 
• "MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway". Molecular Biology of the Cell 24 (1): 42–55. January 2013. doi:10.1091/mbc.E12-07-0519. PMID 23135998. 
• "microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma". Cancer Research 68 (10): 3566–72. May 2008. doi:10.1158/0008-5472.CAN-07-6639. PMID 18483236. 
• "Quantitative differential expression analysis reveals miR-7 as major islet microRNA". Biochemical and Biophysical Research Communications 366 (4): 922–6. February 2008. doi:10.1016/j.bbrc.2007.12.052. PMID 18086561. 
• "[Effects of radiosensitivity and X-ray dose on miR-7 expression in nasopharyngeal carcinoma]". Nan Fang Yi Ke da Xue Xue Bao = Journal of Southern Medical University 30 (8): 1810–2, 1816. August 2010. PMID 20813671. 
• "Regulation of pancreatic microRNA-7 expression". Experimental Diabetes Research 2012: 695214. 2012. doi:10.1155/2012/695214. PMID 22675342. 
• "MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells". Diabetes 62 (3): 887–95. March 2013. doi:10.2337/db12-0451. PMID 23223022. 
• "MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts". Aging Cell 13 (2): 235–44. April 2014. doi:10.1111/acel.12167. PMID 24134702. 
• "17β-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-γ/STAT1-dependent miR-7 upregulation". Aging Cell 15 (3): 531–41. June 2016. doi:10.1111/acel.12462. PMID 26931423. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.