Biology:MIZ zinc finger
From HandWiki
| zf-MIZ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | zf-MIZ | ||||||||
| Pfam | PF02891 | ||||||||
| Pfam clan | CL0229 | ||||||||
| InterPro | IPR004181 | ||||||||
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In molecular biology the MIZ-type zinc finger domain is a zinc finger-containing protein with homology to the yeast protein, Nfi-1. Miz1 is a sequence specific DNA binding protein that can function as a positive-acting transcription factor. Miz1 binds to the homeobox protein Msx2, enhancing the specific DNA-binding ability of Msx2.[1] Other proteins containing this domain include the human pias family (protein inhibitor of activated STAT protein). The name MIZ is derived from Msx-interacting-zinc finger. The crystal structure of S. cerevisiae sumo e3 ligase siz1 containing this domain has been solved.
References
- ↑ "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA". Mech. Dev. 65 (1–2): 3–17. July 1997. doi:10.1016/S0925-4773(97)00032-4. PMID 9256341.
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