Biology:MKNK2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.

Interactions

MNK2 has been shown to interact with MAPK1 and Eukaryotic translation initiation factor 4 gamma.

MNK2 has been identified as a therapeutic target for diabetes. Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promote beta cell regeneration.

Further reading

• "Identification of additional members of human G-protein-coupled receptor kinase multigene family". Proceedings of the National Academy of Sciences of the United States of America 90 (20): 9398–9402. October 1993. doi:10.1073/pnas.90.20.9398. PMID 8415712. Bibcode: 1993PNAS...90.9398H. 
• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. September 1996. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". The EMBO Journal 16 (8): 1909–1920. April 1997. doi:10.1093/emboj/16.8.1909. PMID 9155017. 
• "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells". Molecular and Cellular Biology 21 (3): 743–754. February 2001. doi:10.1128/MCB.21.3.743-754.2001. PMID 11154262. 
• "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2". Molecular and Cellular Biology 21 (16): 5500–5511. August 2001. doi:10.1128/MCB.21.16.5500-5511.2001. PMID 11463832. 
• "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Molecular and Cellular Biology 23 (16): 5692–5705. August 2003. doi:10.1128/MCB.23.16.5692-5705.2003. PMID 12897141. 
• "Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway". Journal of Virology 79 (17): 11366–11381. September 2005. doi:10.1128/JVI.79.17.11366-11381.2005. PMID 16103188. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site". Structure 13 (10): 1559–1568. October 2005. doi:10.1016/j.str.2005.07.013. PMID 16216586. 
• "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. January 2006. doi:10.1101/gr.4039406. PMID 16344560. 
• "Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex". Science in China Series C: Life Sciences 49 (3): 265–273. June 2006. doi:10.1007/s11427-006-0265-5. PMID 16856496.