Biology:MX1
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.[1][2]
In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. Furthermore, the human orthologue MxA is a major host determinant for influenza viruses of animal origin.[3] The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases.[2]
References
- ↑ "Interferon-induced Mx proteins in antiviral host defense". Biochimie 89 (6–7): 812–818. Jul 2007. doi:10.1016/j.biochi.2007.04.015. PMID 17570575.
- ↑ 2.0 2.1 "Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4599.
- ↑ "Influenza A Viruses: Understanding Human Host Determinants". Trends in Molecular Medicine 27 (2): 104–112. Feb 2021. doi:10.1016/j.molmed.2020.09.014. PMID 33097424.
Further reading
- "Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle". Journal of Virology 66 (4): 2564–2569. Apr 1992. doi:10.1128/JVI.66.4.2564-2569.1992. PMID 1548781.
- "Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins". Journal of Virology 66 (8): 4705–4709. Aug 1992. doi:10.1128/JVI.66.8.4705-4709.1992. PMID 1629950.
- "A genetic linkage map of 27 markers on human chromosome 21". Genomics 9 (3): 407–419. Mar 1991. doi:10.1016/0888-7543(91)90406-5. PMID 1674496.
- "Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter". Journal of Virology 64 (3): 1171–1181. Mar 1990. doi:10.1128/JVI.64.3.1171-1181.1990. PMID 2154602.
- "Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein". Journal of Virology 64 (7): 3370–3375. Jul 1990. doi:10.1128/JVI.64.7.3370-3375.1990. PMID 2161946.
- "cDNA structures and regulation of two interferon-induced human Mx proteins". Molecular and Cellular Biology 9 (11): 5062–5072. Nov 1989. doi:10.1128/mcb.9.11.5062. PMID 2481229.
- "Purification and characterization of a human Mx protein". Journal of Interferon Research 9 (6): 679–689. Dec 1989. doi:10.1089/jir.1989.9.679. PMID 2607176.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope". Journal of Biological Chemistry 271 (38): 23478–23486. Sep 1996. doi:10.1074/jbc.271.38.23478. PMID 8798556.
- "Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity". Journal of Virology 71 (4): 2591–2599. Apr 1997. doi:10.1128/JVI.71.4.2591-2599.1997. PMID 9060610.
- "Impaired interferon induction of human MxA protein in chronic hepatitis B virus infection". Journal of Medical Virology 51 (4): 332–337. Apr 1997. doi:10.1002/(SICI)1096-9071(199704)51:4<332::AID-JMV12>3.0.CO;2-K. PMID 9093949.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups". The Journal of Clinical Investigation 100 (11): 2873–2880. Dec 1997. doi:10.1172/JCI119836. PMID 9389754.
- "MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures". Methods (San Diego, Calif.) 15 (3): 255–263. Jul 1998. doi:10.1006/meth.1998.0629. PMID 9735310.
- "MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes". Journal of Virology 74 (1): 560–563. Jan 2000. doi:10.1128/JVI.74.1.560-563.2000. PMID 10590150.
- "Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon". Intervirology 43 (2): 124–127. 2000. doi:10.1159/000025035. PMID 10971132.
- "Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies". Experimental Cell Research 271 (2): 286–295. Dec 2001. doi:10.1006/excr.2001.5380. PMID 11716541.
- "Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro". Intervirology 44 (6): 379–382. 2002. doi:10.1159/000050075. PMID 11805446.
- "Self-assembly of human MxA GTPase into highly ordered dynamin-like oligomers". Journal of Biological Chemistry 277 (16): 14172–14176. Apr 2002. doi:10.1074/jbc.M200244200. PMID 11847228.
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