Biology:Magnesium chelatase
| Magnesium chelatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Magnesium chelatase hetero12mer, Rhodobacter capsulatus | |||||||||
| Identifiers | |||||||||
| EC number | 6.6.1.1 | ||||||||
| CAS number | 9074-88-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Magnesium chelatase, ChlI subunit | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | Mg_chelatse_chII | ||||||||||
| Pfam | PF01078 | ||||||||||
| InterPro | IPR000523 | ||||||||||
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| CobN/magnesium chelatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CobN/Mg_chltase | ||||||||
| Pfam | PF02514 | ||||||||
| InterPro | IPR003672 | ||||||||
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Magnesium-chelatase is a three-component enzyme (EC 6.6.1.1) that catalyses the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of chlorophyll and bacteriochlorophyll.[1][2] As a result, it is thought that Mg-chelatase has an important role in channeling intermediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth:
- REDIRECT Template:Chemical reaction
The four substrates of this enzyme are protoporphyrin IX, magnesium ion, adenosine triphosphate (ATP), and water. Its products are magnesium protoporphyrin IX, adenosine diphosphate (ADP), phosphate (Pi), and two protons.[3][4][5]
This enzyme belongs to the family of ligases, specifically those forming nitrogen-D-metal bonds in coordination complexes. The systematic name of this enzyme class is Mg-protoporphyrin IX magnesium-lyase. Other names in common use include protoporphyrin IX magnesium-chelatase, protoporphyrin IX Mg-chelatase, magnesium-protoporphyrin IX chelatase, magnesium-protoporphyrin chelatase, magnesium-chelatase, Mg-chelatase, and Mg-protoporphyrin IX magnesio-lyase. This enzyme is part of the biosynthetic pathway to chlorophylls.[6]
See also
References
- ↑ Willows, Robert D. (2003). "Biosynthesis of chlorophylls from protoporphyrin IX". Natural Product Reports 20 (6): 327–341. doi:10.1039/B110549N. PMID 12828371.
- ↑ Bollivar, David W. (2007). "Recent advances in chlorophyll biosynthesis". Photosynthesis Research 90 (2): 173–194. doi:10.1007/s11120-006-9076-6. PMID 17370354.
- ↑ "In vitro assay of the chlorophyll biosynthetic enzyme Mg-chelatase: resolution of the activity into soluble and membrane-bound fractions". Proc. Natl. Acad. Sci. U.S.A. 88 (13): 5789–93. 1991. doi:10.1073/pnas.88.13.5789. PMID 11607197. Bibcode: 1991PNAS...88.5789W.
- ↑ "Mechanism and regulation of Mg-chelatase". Biochem. J. 327 (2): 321–33. Oct 15, 1997. doi:10.1042/bj3270321. PMID 9359397.
- ↑ Al-Karadaghi S; Hansson, A; Hansson, M; Olsen, JG; Gough, S; Willows, RD; Al-Karadaghi, S (2001). "Interplay between an AAA module and an integrin I domain may regulate the function of magnesium chelatase". J. Mol. Biol. 311 (1): 111–22. doi:10.1006/jmbi.2001.4834. PMID 11469861.
- ↑ Enzyme 6.6.1.1 at KEGG Pathway Database.
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