Biology:Major vault protein
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Major vault protein (MVP), also known as lung resistance-related protein (LRP) is a protein that in humans is encoded by the MVP gene.[1][2] 78 copies of the protein assemble into the large compartments called vaults.
Function
This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.[2]
Major vault protein coimmunoprecipitates with the human estrogen receptor and treatment with estradiol increases MVP associated with the estrogen receptor in nuclear extracts.[3]
Interactions
Major vault protein has been shown to interact with Estrogen receptor alpha,[4] PTEN[5] and PARP4.[6][7]
References
- ↑ "The drug resistance-related protein LRP is the human major vault protein". Nature Medicine 1 (6): 578–82. Jun 1995. doi:10.1038/nm0695-578. PMID 7585126. https://pure.knaw.nl/portal/en/publications/the-drugresistancerelated-protein-lrp-is-the-human-major-vault-protein(c49e6086-ede3-4b91-ac6e-4ab9158c6cac).html.
- ↑ 2.0 2.1 "Entrez Gene: MVP major vault protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9961.
- ↑ Kong, Lawrence B; Siva, Amara C; Rome, Leonard H; Stewart, Phoebe L (April 1999). "Structure of the vault, a ubiquitous celular component". Structure 7 (4): 371–379. doi:10.1016/s0969-2126(99)80050-1. ISSN 0969-2126. http://dx.doi.org/10.1016/s0969-2126(99)80050-1.
- ↑ "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology 141 (6): 1301–10. Jun 1998. doi:10.1083/jcb.141.6.1301. PMID 9628887.
- ↑ "PTEN associates with the vault particles in HeLa cells". The Journal of Biological Chemistry 277 (43): 40247–52. Oct 2002. doi:10.1074/jbc.M207608200. PMID 12177006. https://www.openaccessrepository.it/record/94755/files/fulltext.pdf.
- ↑ "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochemical and Biophysical Research Communications 291 (3): 535–41. Mar 2002. doi:10.1006/bbrc.2002.6472. PMID 11855821.
- ↑ "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". The Journal of Cell Biology 146 (5): 917–28. Sep 1999. doi:10.1083/jcb.146.5.917. PMID 10477748.
Further reading
- "Major vault protein LRP-related multidrug resistance". European Journal of Cancer 32A (6): 979–84. Jun 1996. doi:10.1016/0959-8049(96)00053-6. PMID 8763338.
- "The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification". Cancer Research 55 (19): 4214–9. Oct 1995. PMID 7671223.
- "Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors". The American Journal of Pathology 148 (3): 877–87. Mar 1996. PMID 8774142.
- "Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues". Annals of Oncology 7 (6): 625–30. Aug 1996. doi:10.1093/oxfordjournals.annonc.a010681. PMID 8879378.
- "Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP". Cancer Letters 112 (1): 23–31. Jan 1997. doi:10.1016/S0304-3835(96)04542-9. PMID 9029166.
- "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology 141 (6): 1301–10. Jun 1998. doi:10.1083/jcb.141.6.1301. PMID 9628887.
- "Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes". International Journal of Cancer 82 (4): 599–604. Aug 1999. doi:10.1002/(SICI)1097-0215(19990812)82:4<599::AID-IJC21>3.0.CO;2-R. PMID 10404077.
- "The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma". Leukemia & Lymphoma 34 (3–4): 315–24. Jul 1999. doi:10.3109/10428199909050956. PMID 10439368.
- "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". The Journal of Cell Biology 146 (5): 917–28. Sep 1999. doi:10.1083/jcb.146.5.917. PMID 10477748.
- "Vaults and telomerase share a common subunit, TEP1". The Journal of Biological Chemistry 274 (46): 32712–7. Nov 1999. doi:10.1074/jbc.274.46.32712. PMID 10551828.
- "Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter". Biochemical and Biophysical Research Communications 278 (1): 125–33. Nov 2000. doi:10.1006/bbrc.2000.3782. PMID 11071864.
- "A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant". FEBS Letters 494 (1–2): 99–104. Apr 2001. doi:10.1016/S0014-5793(01)02318-3. PMID 11297743.
- "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochemical and Biophysical Research Communications 291 (3): 535–41. Mar 2002. doi:10.1006/bbrc.2002.6472. PMID 11855821.
- "Human T-cell lymphotropic virus type I Tax activates lung resistance-related protein expression in leukemic clones established from an adult T-cell leukemia patient". Experimental Hematology 30 (4): 340–5. Apr 2002. doi:10.1016/S0301-472X(02)00775-0. PMID 11937269.
- "[The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia]". Zhonghua Nei Ke Za Zhi 41 (3): 183–5. Mar 2002. PMID 11940320.
- "Multidrug resistance related molecules in human and murine lung". Journal of Clinical Pathology 55 (5): 332–9. May 2002. doi:10.1136/jcp.55.5.332. PMID 11986335.
- "Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)". Leukemia 16 (5): 833–9. May 2002. doi:10.1038/sj.leu.2402496. PMID 11986944.
- "PTEN associates with the vault particles in HeLa cells". The Journal of Biological Chemistry 277 (43): 40247–52. Oct 2002. doi:10.1074/jbc.M207608200. PMID 12177006. https://www.openaccessrepository.it/record/94755/files/fulltext.pdf.
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