Biology:Major vault protein
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Major vault protein, also known as lung resistance-related protein is a protein that in humans is encoded by the MVP gene.[1][2] 78 copies of the protein assemble into the large compartments called vaults.
Function
This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. Major vault protein comprises 70% of vaults which also contain vPARP and TEP1.[3] This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.[2]
Interactions
Major vault protein coimmunoprecipitates with the human estrogen receptor and treatment with estradiol increases major vault protein associated with the estrogen receptor in nuclear extracts.[4]
Major vault protein has been shown to interact with estrogen receptor alpha,[5] PTEN[6] and PARP4.[7][8]
References
- ↑ "The drug resistance-related protein LRP is the human major vault protein". Nature Medicine 1 (6): 578–582. June 1995. doi:10.1038/nm0695-578. PMID 7585126.
- ↑ 2.0 2.1 "Entrez Gene: MVP major vault protein". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9961.
- ↑ "Vaults and the major vault protein: novel roles in signal pathway regulation and immunity". Cellular and Molecular Life Sciences 66 (1): 43–61. January 2009. doi:10.1007/s00018-008-8364-z. PMID 18759128.
- ↑ "Structure of the vault, a ubiquitous celular component". Structure 7 (4): 371–379. April 1999. doi:10.1016/s0969-2126(99)80050-1. PMID 10196123.
- ↑ "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology 141 (6): 1301–1310. June 1998. doi:10.1083/jcb.141.6.1301. PMID 9628887.
- ↑ "PTEN associates with the vault particles in HeLa cells". The Journal of Biological Chemistry 277 (43): 40247–40252. October 2002. doi:10.1074/jbc.M207608200. PMID 12177006.
- ↑ "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochemical and Biophysical Research Communications 291 (3): 535–541. March 2002. doi:10.1006/bbrc.2002.6472. PMID 11855821.
- ↑ "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". The Journal of Cell Biology 146 (5): 917–928. September 1999. doi:10.1083/jcb.146.5.917. PMID 10477748.
Further reading
- "Major vault protein LRP-related multidrug resistance". European Journal of Cancer 32A (6): 979–984. June 1996. doi:10.1016/0959-8049(96)00053-6. PMID 8763338.
- "The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification". Cancer Research 55 (19): 4214–4219. October 1995. PMID 7671223.
- "Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors". The American Journal of Pathology 148 (3): 877–887. March 1996. PMID 8774142.
- "Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues". Annals of Oncology 7 (6): 625–630. August 1996. doi:10.1093/oxfordjournals.annonc.a010681. PMID 8879378.
- "Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP". Cancer Letters 112 (1): 23–31. January 1997. doi:10.1016/S0304-3835(96)04542-9. PMID 9029166. https://research.vumc.nl/en/publications/1d0905cc-92fe-4944-b648-1c8d412c9893.
- "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology 141 (6): 1301–1310. June 1998. doi:10.1083/jcb.141.6.1301. PMID 9628887.
- "Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes". International Journal of Cancer 82 (4): 599–604. August 1999. doi:10.1002/(SICI)1097-0215(19990812)82:4<599::AID-IJC21>3.0.CO;2-R. PMID 10404077.
- "The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma". Leukemia & Lymphoma 34 (3–4): 315–324. July 1999. doi:10.3109/10428199909050956. PMID 10439368.
- "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". The Journal of Cell Biology 146 (5): 917–928. September 1999. doi:10.1083/jcb.146.5.917. PMID 10477748.
- "Vaults and telomerase share a common subunit, TEP1". The Journal of Biological Chemistry 274 (46): 32712–32717. November 1999. doi:10.1074/jbc.274.46.32712. PMID 10551828.
- "Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter". Biochemical and Biophysical Research Communications 278 (1): 125–133. November 2000. doi:10.1006/bbrc.2000.3782. PMID 11071864.
- "A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant". FEBS Letters 494 (1–2): 99–104. April 2001. doi:10.1016/S0014-5793(01)02318-3. PMID 11297743. Bibcode: 2001FEBSL.494...99H.
- "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochemical and Biophysical Research Communications 291 (3): 535–541. March 2002. doi:10.1006/bbrc.2002.6472. PMID 11855821.
- "Human T-cell lymphotropic virus type I Tax activates lung resistance-related protein expression in leukemic clones established from an adult T-cell leukemia patient". Experimental Hematology 30 (4): 340–345. April 2002. doi:10.1016/S0301-472X(02)00775-0. PMID 11937269.
- "[The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia]". Zhonghua Nei Ke Za Zhi 41 (3): 183–185. March 2002. PMID 11940320.
- "Multidrug resistance related molecules in human and murine lung". Journal of Clinical Pathology 55 (5): 332–339. May 2002. doi:10.1136/jcp.55.5.332. PMID 11986335.
- "Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)". Leukemia 16 (5): 833–839. May 2002. doi:10.1038/sj.leu.2402496. PMID 11986944.
- "PTEN associates with the vault particles in HeLa cells". The Journal of Biological Chemistry 277 (43): 40247–40252. October 2002. doi:10.1074/jbc.M207608200. PMID 12177006.
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