Biology:Malonyl-CoA O-methyltransferase
From HandWiki
| Malonyl-CoA O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.197 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Malonyl-CoA O-methyltransferase (EC 2.1.1.197, BioC) is an enzyme with systematic name S-adenosyl-L-methionine:malonyl-CoA O-methyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + malonyl-CoA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + malonyl-CoA methyl ester
Malonyl-CoA O-methyltransferase is involved in an early step of biotin biosynthesis in Gram-negative bacteria.
References
- ↑ "Biotin-requiring mutants of Escherichia coli K-12". Journal of Bacteriology 94 (6): 2065–6. December 1967. PMID 4864413.
- ↑ "Genetic and biochemical analysis of the biotin loci of Escherichia coli K-12". Journal of Bacteriology 96 (2): 515–24. August 1968. PMID 4877129.
- ↑ "The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon". The Journal of Biological Chemistry 263 (36): 19577–85. December 1988. PMID 3058702.
- ↑ "Deletion and complementation analysis of biotin gene cluster of Escherichia coli". Journal of Bacteriology 112 (2): 830–9. November 1972. PMID 4563978.
- ↑ "Biotin synthesis begins by hijacking the fatty acid synthetic pathway". Nature Chemical Biology 6 (9): 682–8. September 2010. doi:10.1038/nchembio.420. PMID 20693992.
External links
- Malonyl-CoA+O-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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