Biology:Mammillothalamic tract
| Mammillothalamic tract | |
|---|---|
| Details | |
| Identifiers | |
| Latin | fasciculus mammillothalamicus |
| Anatomical terminology | |
The mammillothalamic tract (also mammillary fasciculus,[1] mammillothalamic fasciculus, thalamomammillary fasciculus, bundle of Vicq d’Azyr) is an efferent pathway of the mammillary body which projects to the anterior nuclei of thalamus. It consists of heavily myelinated fibres.[1] It is part of a brain circuit involved in spatial memory.[2][3]
It arises from (the medial and lateral nuclei of) the mammillary body and from fibers that are directly continued from the fornix.[2][3] It connects the mammillary body to the dorsal tegmental nuclei, the ventral tegmental nuclei, and the anterior thalamic nuclei.[2][3][4]
Structure
Axons divide within the gray matter; the thicker fibres form the MTT while the finer branches descend as the mammillotegmental fasciculus.[2] The MTT spreads fan-like as it terminates in the medial dorsal nucleus.[2] Some fibers pass through the dorsal nucleus to the angular nucleus of the thalamus. (a group of cells ventral to the lateral dorsal nucleus of thalamus[5]). The axons from these nuclei form part of the thalamocortical radiations.[6]
Clinical significance
Infarction of the region including the mammillothalamic tract has been associated with alcoholic Korsakoff syndrome.[7]
History
The mammillothalamic tract was first described by the French physician, Félix Vicq d'Azyr, from whom it takes its alternate name (bundle of Vicq d'Azyr).[2]
See also
- Hypothalamotegmental tract
- Papez circuit
References
- ↑ 1.0 1.1 Patestas, Maria A.; Gartner, Leslie P. (2016). A Textbook of Neuroanatomy (2nd ed.). Hoboken, New Jersey: Wiley-Blackwell. pp. 434. ISBN 978-1-118-67746-9.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Dillingham, C. M; Frizzati, A; Nelson, A. J; Vann, S. D (2015). "How do mammillary body inputs contribute to anterior thalamic function?". Neuroscience & Biobehavioral Reviews 54: 108–119. doi:10.1016/j.neubiorev.2014.07.025. PMID 25107491.
- ↑ 3.0 3.1 3.2 Aggleton, J. P; O'Mara, S. M; Vann, S. D; Wright, N. F; Tsanov, M; Erichsen, J. T (2010). "Hippocampal–anterior thalamic pathways for memory: Uncovering a network of direct and indirect actions". European Journal of Neuroscience 31 (12): 2292–2307. doi:10.1111/j.1460-9568.2010.07251.x. PMID 20550571.
- ↑ Haines DE (2003). Neuroanatomy: Atlas of Structures, Sections, and Systems, 6th ed (page 148). Lippincott Williams & Wilkins. ISBN 978-0781746779. https://books.google.com/books?id=xP-kmKiziAQC&pg=PA148.
- ↑ NeuroNames. Angular Thalamic Nucleus --> "What, Where and How Big is It?" BrainInfo. Accessed January 25, 2011.
- ↑ Kamali, Arash; Zhang, Caroline C.; Riascos, Roy F.; Tandon, Nitin; Bonafante-Mejia, Eliana E.; Patel, Rajan; Lincoln, John A.; Rabiei, Pejman et al. (2018-03-27). "Diffusion tensor tractography of the mammillothalamic tract in the human brain using a high spatial resolution DTI technique". Scientific Reports 8 (1): 5229. doi:10.1038/s41598-018-23452-w. ISSN 2045-2322. PMID 29588461. Bibcode: 2018NatSR...8.5229K.
- ↑ "Acute Korsakoff syndrome following mammillothalamic tract infarction". AJNR Am J Neuroradiol 25 (6): 964–8. 2004. PMID 15205131. http://www.ajnr.org/content/25/6/964.long.
External links
- ancil-115 at NeuroNames - "mammillothalamic tract"
- hier-407 at NeuroNames - "mammillothalamic tract of hypothalamus"
- hier-356 at NeuroNames - "mammillothalamic tract of thalamus"
- https://web.archive.org/web/20080505050804/http://isc.temple.edu/neuroanatomy/lab/atlas/dan2/
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