Biology:Methionyl-tRNA formyltransferase
Methionyl-tRNA formyltransferase | |||||||||
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![]() Structure de Fmt chez Escherichia coli | |||||||||
Identifiers | |||||||||
EC number | 2.1.2.9 | ||||||||
CAS number | 9015-76-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a methionyl-tRNA formyltransferase (EC 2.1.2.9) is an enzyme that catalyzes the chemical reaction
- 10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O [math]\displaystyle{ \rightleftharpoons }[/math] tetrahydrofolate + N-formylmethionyl-tRNAfMet
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase. Other names in common use include N10-formyltetrahydrofolic-methionyl-transfer ribonucleic, transformylase, formylmethionyl-transfer ribonucleic synthetase, methionyl ribonucleic formyltransferase, methionyl-tRNA Met formyltransferase, methionyl-tRNA transformylase, methionyl-transfer RNA transformylase, methionyl-transfer ribonucleate methyltransferase, and methionyl-transfer ribonucleic transformylase. This enzyme participates in 3 metabolic pathways: methionine metabolism, one carbon pool by folate, and aminoacyl-tRNA biosynthesis.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1FMT and 2FMT.
References
- "Methionyl soluble ribonucleic acid transformylase. I. Purification and partial characterization". J. Biol. Chem. 242 (7): 1522–5. 1967. PMID 5337045.
![]() | Original source: https://en.wikipedia.org/wiki/Methionyl-tRNA formyltransferase.
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