Biology:Methylphenyltetrahydropyridine N-monooxygenase

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Methylphenyltetrahydropyridine N-monooxygenase
Identifiers
EC number1.13.12.11
CAS number37256-73-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Methylphenyltetrahydropyridine N-monooxygenase (EC 1.13.12.11) is an enzyme with systematic name 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + O2 [math]\displaystyle{ \rightleftharpoons }[/math] 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + methanol

Methylphenyltetrahydropyridine N-monooxygenase is a flavoprotein.

References

  1. "Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice". The Journal of Pharmacology and Experimental Therapeutics 246 (3): 1108–15. September 1988. PMID 3262153. 

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