Biology:MicC RNA
From HandWiki
| MicC RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of MicC | |
| Identifiers | |
| Symbol | MicC |
| Alt. Symbols | IS063 |
| Rfam | RF00121 |
| Other data | |
| RNA type | Gene; sRNA |
| Domain(s) | Bacteria |
| SO | 0000655 |
| PDB structures | PDBe |
The MicC non-coding RNA (previously known as IS063 [1]) is located between the ompN and ydbK genes in E. coli. This Hfq-associated RNA is thought to be a regulator of the expression level of the OmpC porin protein, with a 5′ region of 22 nucleotides potentially forming an antisense interaction with the ompC mRNA. Along with MicF RNA this family may act in conjunction with EnvZ-OmpR two-component system to control the OmpF/OmpC protein ratio in response to a variety of environmental stimuli.[2] The expression of micC was shown to be increased in the presence of beta-lactam antibiotics.[3]
See also
References
- ↑ "A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome". Bio Systems 65 (2–3): 157–177. 2002. doi:10.1016/S0303-2647(02)00013-8. PMID 12069726.
- ↑ "MicC, a second small-RNA regulator of Omp protein expression in Escherichia coli". Journal of Bacteriology 186 (20): 6689–6697. October 2004. doi:10.1128/JB.186.20.6689-6697.2004. PMID 15466019.
- ↑ "Dual Regulation of the Small RNA MicC and the Quiescent Porin OmpN in Response to Antibiotic Stress in Escherichia coli". Antibiotics 6 (4): 33. December 2017. doi:10.3390/antibiotics6040033. PMID 29211019.
Further reading
- "Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation". Nature Structural & Molecular Biology 16 (8): 840–846. August 2009. doi:10.1038/nsmb.1631. PMID 19620966.
External links
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