Biology:Mir-592 microRNA precursor family
From HandWiki
| mir-592 | |
|---|---|
| Identifiers | |
| Symbol | mir-592 |
| Rfam | RF00877 |
| miRBase family | MIPF0000340 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-592 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Expression in cancers
Significantly altered expression of miR-592 has been observed between tumours deficient and proficient for mismatch repair in colon cancer.[1] Expression levels are lower in the proficient form compared to the deficient, with a more than two-fold change.[2] This altered expression has been proposed to reflect a reversion to regulatory programs seen in earlier undifferentiated and proliferative developmental states.
miR-592 expression is also altered in hepatocellular carcinoma; it has been shown to be downregulated along with nine other microRNAs.
See also
References
- ↑ "Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states.". BMC Cancer 9: 401. 2009. doi:10.1186/1471-2407-9-401. PMID 19922656.
- ↑ "miRNA expression in colon polyps provides evidence for a multihit model of colon cancer.". PLOS ONE 6 (6): e20465. 2011. doi:10.1371/journal.pone.0020465. PMID 21694772. Bibcode: 2011PLoSO...620465O.
Further reading
- Wang, W.; Zhao, L. -J.; Tan, Y. -X.; Ren, H.; Qi, Z. -T. (2012). "MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma". Carcinogenesis 33 (5): 1113–1120. doi:10.1093/carcin/bgs113. PMID 22362728.
External links
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