Biology:Mir-744 microRNA precursor family
| mir-744 | |
|---|---|
| Identifiers | |
| Symbol | mir-744 |
| Rfam | RF00936 |
| miRBase family | MIPF0000431 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-744 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-744 and cancer in mice
miR-744 plays a role in tumour development and growth in mouse cell lines. Its expression induces cyclin B1 expression, whilst knockdown sees a resultant decreased level of mouse cyclin B through the Ccnb1 gene.[1] Short-term overexpression of miR-744 in mouse cell lines has been seen to enhance cell proliferation, whilst chromosomal instability and in vivo suppression are concurrent with a prolonged expression.
TGF-β1 repression
Multiple miR-744 binding sites have been identified in the proximal 3' untranslated region of transforming growth factor beta 1 (TGF-β1). Direct targeting of TGF-β1 by miR-744 has been identified, and transfection is seen to inhibit endogenous TGF-β1 synthesis by directing post-transcriptional regulation.[2]
EEF1A2 repression
miR-744 directly targets translation elongation factor and known protooncogene EEF1A2.[3] mIR-744 also upregulates during resveratrol treatment of MCF7 breast cancer cells.[4]
See also
References
- ↑ "Upregulation of Cyclin B1 by miRNA and its implications in cancer.". Nucleic Acids Res 40 (4): 1695–707. 2012. doi:10.1093/nar/gkr934. PMID 22053081.
- ↑ "Post-transcriptional regulation of Transforming Growth Factor Beta-1 by microRNA-744.". PLOS ONE 6 (10): e25044. 2011. doi:10.1371/journal.pone.0025044. PMID 21991303. Bibcode: 2011PLoSO...625044M.
- ↑ Vislovukh, A; Kratassiouk, G; Porto, E; Gralievska, N; Beldiman, C; Pinna, G; El'skaya, A; Harel-Bellan, A et al. (11 June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744.". British Journal of Cancer 108 (11): 2304–11. doi:10.1038/bjc.2013.243. PMID 23695020.
- ↑ Vislovukh, A; Kratassiouk, G; Porto, E; Gralievska, N; Beldiman, C; Pinna, G; El'skaya, A; Harel-Bellan, A et al. (11 June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744.". British Journal of Cancer 108 (11): 2304–11. doi:10.1038/bjc.2013.243. PMID 23695020.
Further reading
- Song, M. Y.; Pan, K. F.; Su, H. J.; Zhang, L.; Ma, J. L.; Li, J. Y.; Yuasa, Y.; Kang, D. et al. (2012). Califano, Joseph. ed. "Identification of Serum MicroRNAs as Novel Non-Invasive Biomarkers for Early Detection of Gastric Cancer". PLOS ONE 7 (3): e33608. doi:10.1371/journal.pone.0033608. PMID 22432036. Bibcode: 2012PLoSO...733608S.
- Mi, Q. S.; Weiland, M.; Qi, R. Q.; Gao, X. H.; Poisson, L. M.; Zhou, L. (2012). Homberg, Judith. ed. "Identification of Mouse Serum miRNA Endogenous References by Global Gene Expression Profiles". PLOS ONE 7 (2): e31278. doi:10.1371/journal.pone.0031278. PMID 22348064. Bibcode: 2012PLoSO...731278M.
- Chen, Y. Q.; Wang, X. X.; Yao, X. M.; Zhang, D. L.; Yang, X. F.; Tian, S. F.; Wang, N. S. (2012). "Abated microRNA-195 expression protected mesangial cells from apoptosis in early diabetic renal injury in mice". Journal of Nephrology 25 (4): 566–576. doi:10.5301/jn.5000034. PMID 21983986.
- Yoke-Kqueen, C.; Yoke-Kqueen, C.; Sabariah, A. R.; Shiran, M. S.; Singh, A.; Learn-Han, L. (2011). "Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers". International Journal of Molecular Medicine 28 (3): 327–336. doi:10.3892/ijmm.2011.714. PMID 21637912.
External links
 |  |
