Biology:NAV2
 Generic protein structure example |
Neuron navigator 2 is a protein that in humans is encoded by the NAV2 gene.[1][2][3] The vitamin A metabolite, all-trans retinoic acid (atRA), plays an important role in neuronal development, including neurite outgrowth. NAV2 is an atRA-responsive gene.[3]
The neuron navigator, Is also theorized to play a role in cellular growth and migration.[4] In addition, different isoform variants have been discovered for this gene. Connections have been drawn to Nav2 having an association with human neurocognitive disorders Alzheimer's disease and age-related phenotypes. It has been discussed that future studies of Nav2 could provide crucial information in understanding the pathophysiology of the disease and its related phenotypes.[5]
NAV2 association
The NAV2 gene, which is extensively expressed in the brain and is important to nervous system development, may play a role in Alzheimer's disease.[6] Alzheimer's disease is a chronic neurological illness whose prevalence rises rapidly as people reach the age of 65. According to reports, Alzheimer's disease is one of the top ten main causes of death in the United States.There are 50 introns and 38 exons in the neuron navigator 2 (NAV2) gene.[6] The NAV2 gene was shown to be strongly expressed in the brain, as well as the kidney, liver, thyroid, mammary gland, and spinal cord (and may be involved in cell proliferation, migration, and nervous system development).[6] NAV2 has recently been linked to episodic memory scores in Alzheimer's patients.To date, no study has looked into the link between the NAV2 gene and the risk or AAO of Alzheimer's disease.[6] NAV2 may be one of the processes linking blood pressure, cardiovascular disease, and neurodegenerative disorders, according to this study. NAV2 was found to be overexpressed in human colorectal cancer in another gene expression analysis, suggesting that it could be used as a predictive biomarker as well as a possible therapeutic target for colorectal cancer. However, the conducted study may have some limitations, so more research is needed to adequately understand the purpose of NAV2.[6]
References
- ↑ "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans". Genomics 80 (1): 21–30. Jun 2002. doi:10.1006/geno.2002.6799. PMID 12079279.
- ↑ "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms". Gene 290 (1–2): 73–94. Jun 2002. doi:10.1016/S0378-1119(02)00567-X. PMID 12062803.
- ↑ 3.0 3.1 "Entrez Gene: NAV2 neuron navigator 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89797.
- ↑ "NAV2 neuron navigator 2 [Homo sapiens (human) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=89797.
- ↑ Xu, Chun; Su, Brenda Bin; Lozano, Stephanie; Wang, Kesheng (2020-01-01), Martin, Colin R.; Preedy, Victor R., eds., "Chapter 1 - The neuron navigator 2 gene and Alzheimer's disease" (in en), Genetics, Neurology, Behavior, and Diet in Dementia (Academic Press): pp. 3–24, ISBN 978-0-12-815868-5, https://www.sciencedirect.com/science/article/pii/B9780128158685000013, retrieved 2022-05-05
- ↑ 6.0 6.1 6.2 6.3 6.4 Wang, Ke-Sheng; Liu, Ying; Xu, Chun; Liu, Xuefeng; Luo, Xingguang (2017-09-15). "Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease". Journal of Neuroimmunology 310: 60–65. doi:10.1016/j.jneuroim.2017.06.010. ISSN 0165-5728. PMID 28778446.
Further reading
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. 2003. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Xu, Chun; Su, Brenda Bin; Lozano, Stephanie; Wang, Kesheng (2020-01-01), Martin, Colin R.; Preedy, Victor R., eds., "Chapter 1 - The neuron navigator 2 gene and Alzheimer's disease" (in en), Genetics, Neurology, Behavior, and Diet in Dementia (Academic Press): pp. 3–24, ISBN 978-0-12-815868-5, https://www.sciencedirect.com/science/article/pii/B9780128158685000013, retrieved 2022-05-05
- "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. 1997. doi:10.1101/gr.6.9.807. PMID 8889549.
- "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. 2000. doi:10.1093/dnares/7.1.65. PMID 10718198.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3422–7. 2002. doi:10.1073/pnas.052017399. PMID 11904404. Bibcode: 2002PNAS...99.3422M.
- "Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas". Oncogene 21 (41): 6387–94. 2002. doi:10.1038/sj.onc.1205751. PMID 12214280.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. 2004. doi:10.1074/jbc.M312867200. PMID 15031288.
- "The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. 2004. doi:10.1086/421527. PMID 15124103.
- "Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53". Brain Res. Dev. Brain Res. 150 (2): 89–101. 2004. doi:10.1016/j.devbrainres.2004.03.004. PMID 15158073.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. 2006. doi:10.1038/nbt1240. PMID 16964243.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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