Biology:Nicotianamine aminotransferase

From HandWiki
Nicotianamine aminotransferase
Identifiers
EC number2.6.1.80
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Nicotianamine aminotransferase (EC 2.6.1.80) is an enzyme that catalyzes the chemical reaction

  1. REDIRECT Template:Chemical reaction

The two substrates of this enzyme are nicotianamine and 2-oxoglutaric acid. Its products are 3"-deamino-3"-oxonicotianamine and glutamic acid.[1][2][3]

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is nicotianamine:2-oxoglutarate aminotransferase; nicotianamine transaminase. Other names in common use include NAAT, NAAT-I, NAAT-II, and NAAT-III.

Both the starting material and product of this enzyme are phytosiderophores that help higher plants absorb metal ions from soil.[4][5]

References

  1. Enzyme 2.6.1.80 at KEGG Pathway Database.
  2. Mori S; Higuchi, Kyoko; Nishizawa, Naoko-Kishi; Fushiya, Shinji; Chino, Mitsuo; Mori, Satoshi (1994). "Nicotianamine aminotransferase activities are correlated with the phytosiderophore secretions under Fe-deficient conditions in Gramineae". J. Exp. Bot. 45 (12): 1903–1906. doi:10.1093/jxb/45.12.1903. 
  3. "ZmYS1 functions as a proton-coupled symporter for phytosiderophore- and nicotianamine-chelated metals". J. Biol. Chem. 279 (10): 9091–6. 2004. doi:10.1074/jbc.M311799200. PMID 14699112. 
  4. S; Yamaguchi, H; Nakanishi, H; Shioiri, T; Nishizawa, NK; Mori, S (1999). "Cloning Two Genes for Nicotianamine Aminotransferase, a Critical Enzyme in Iron Acquisition (Strategy II) in Graminaceous Plants". Plant Physiol. 121 (3): 947–56. doi:10.1104/pp.121.3.947. PMID 10557244. 
  5. Marschner, Horst (2012). Marschner's Mineral Nutrition of Higher Plants. London Waltham, MA: Academic Press. ISBN 978-0-12-384905-2. https://www.google.co.uk/books/edition/Marschner_s_Mineral_Nutrition_of_Higher/_a-hKcXXQuAC?hl=en&gbpv=1&printsec=frontcover&bsq=nicotianamine.