Biology:O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase
From HandWiki
| O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase | |||||||||
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 Selenocysteine synthase tetramer, Mus musculus | |||||||||
| Identifiers | |||||||||
| EC number | 2.9.1.2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase (EC 2.9.1.2, MMPSepSecS, SepSecS, SLA/LP, O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase, O-phospho-L-seryl-tRNA:L-selenocysteinyl-tRNA synthase) is an enzyme with systematic name selenophosphate:O-phospho-L-seryl-tRNASec selenium transferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- O-phospho-L-seryl-tRNASec + selenophosphate ⇌ L-selenocysteinyl-tRNASec + phosphate
This enzyme is pyridoxal-phosphate protein.
References
- ↑ "The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation". Science 325 (5938): 321–5. July 2009. doi:10.1126/science.1173755. PMID 19608919. Bibcode: 2009Sci...325..321P.
- ↑ "Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation". Nucleic Acids Research 36 (4): 1187–99. March 2008. doi:10.1093/nar/gkm1122. PMID 18158303.
- ↑ "The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes". Proceedings of the National Academy of Sciences of the United States of America 106 (13): 5088–92. March 2009. doi:10.1073/pnas.0901575106. PMID 19279205. Bibcode: 2009PNAS..106.5088A.
- ↑ "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proceedings of the National Academy of Sciences of the United States of America 103 (50): 18923–7. December 2006. doi:10.1073/pnas.0609703104. PMID 17142313. Bibcode: 2006PNAS..10318923Y.
External links
- O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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