Biology:OmcS oxidoreductase
OmcS nanowires (Geobacter nanowires) are conductive filaments found in some species of bacteria, including Geobacter sulfurreducens, where they catalyze the transfer of electrons. They are multiheme c-Type cytochromes localized outside of the cell of some exoelectrogenic bacterial species, serving as mediator of extracellular electron transfer from cells to Fe(III) oxides and other extracellular electron acceptors.[1] OmcS (3D structure) has a core of six low-spin bis-histidinyl hexacoordinated heme groups inside a sinusoidal filament ~5-7.4 nm in diameter, with 46.7 Å rise per subunit and 4.3 subunits per turn. The six-heme packing motif of OmcS is identical to that seen in a ~3 nm diameter cytochrome nanowire, OmcE (3D structure), even though OmcE and OmcS share no sequence similarity.[2][3]
The OmcS gene can be one the most highly up-regulated genes in the Geobacter sulfurreducens KN400 strain when cultivated in a microbial fuel cell, as compared to the PCA strain, although a role for OmcS in electron transfer to electrodes has never been demonstrated.[4]
References
- ↑ Qian, X; Mester, T; Morgado, L; Arakawa, T; Sharma, ML; Inoue, K; Joseph, C; Salgueiro, CA et al. (2011). "Biochemical characterization of purified OmcS, a c-type cytochrome required for insoluble Fe(III) reduction in Geobacter sulfurreducens.". Biochimica et Biophysica Acta (BBA) - Bioenergetics 1807 (4): 404–412. doi:10.1016/j.bbabio.2011.01.003. PMID 21236241.
- ↑ Wang (2022). "Cryo-EM structure of an extracellular Geobacter OmcE cytochrome filament reveals tetrahaem packing.". Nature Microbiology 7 (8): 1291–1300. doi:10.1038/s41564-022-01159-z. PMID 35798889.
- ↑ Wang (2019). "Structure of Microbial Nanowires Reveals Stacked Hemes that Transport Electrons over Micrometers.". Cell 177 (2): 361–369.e10. doi:10.1016/j.cell.2019.03.029. PMID 30951668.
- ↑ Butler (2012). "Comparative genomic analysis of Geobacter sulfurreducens KN400, a strain with enhanced capacity for extracellular electron transfer and electricity production.". BMC Genomics 13: 471. doi:10.1186/1471-2164-13-471. PMID 22967216.
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