Biology:P120 (protein)
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
p120, and called catenin delta-1 is a protein that in humans is encoded by the CTNND1 gene.[1]
Function
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.[2]
Clinical significance
Immunohistochemistry for p120 has cytoplasmic staining in invasive lobular carcinoma (shown), but has membranous staining in invasive ductal carcinoma, thereby helping to distinguish these cancer types.
Either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma.[3]
Interactions
CTNND1 has been shown to interact with:
- Beta-catenin,[4][5]
- CDH1,[4][6][7][8][9][10][11][12]
- CDH2,[13][14]
- Collagen, type XVII, alpha 1,[15]
- Cortactin,[16]
- FYN,[6][16]
- MUC1,[17]
- Nephrin,[18]
- PSEN1,[19]
- PTPN6,[20]
- PTPRJ,[21]
- PTPRM,[22]
- VE-cadherin,[23][24]
- YES1,[6] and
- ZBTB33[25]
See also
- Delta catenin
- Catenin
- CTNND2
References
- ↑ "The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)". Genomics 31 (1): 127–9. October 1996. doi:10.1006/geno.1996.0020. PMID 8808291.
- ↑ "Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1500.
- ↑ Schackmann, R. C. J.; Tenhagen, M.; van de Ven, R. A. H.; Derksen, P. W. B. (2013). "p120-catenin in cancer - mechanisms, models and opportunities for intervention". Journal of Cell Science 126 (16): 3515–3525. doi:10.1242/jcs.134411. ISSN 0021-9533. PMID 23950111.
- ↑ 4.0 4.1 "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. 273 (15): 9078–84. April 1998. doi:10.1074/jbc.273.15.9078. PMID 9535896.
- ↑ "Expression and interaction of different catenins in colorectal carcinoma cells". Int. J. Mol. Med. 8 (6): 695–8. December 2001. doi:10.3892/ijmm.8.6.695. PMID 11712088.
- ↑ 6.0 6.1 6.2 "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. 23 (7): 2287–97. 2003. doi:10.1128/MCB.23.7.2287-2297.2003. PMID 12640114.
- ↑ "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. 15 (9): 4819–24. September 1995. doi:10.1128/mcb.15.9.4819. PMID 7651399.
- ↑ "A novel role for p120 catenin in E-cadherin function". J. Cell Biol. 159 (3): 465–76. 2002. doi:10.1083/jcb.200205115. PMID 12427869.
- ↑ "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. 130 (2): 461–71. 1995. doi:10.1083/jcb.130.2.461. PMID 7542250.
- ↑ "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. 2003. doi:10.1083/jcb.200303036. PMID 12707304.
- ↑ "Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes". J. Cell Biol. 128 (5): 949–57. 1995. doi:10.1083/jcb.128.5.949. PMID 7876318.
- ↑ "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity". J. Biol. Chem. 274 (30): 21409–15. July 1999. doi:10.1074/jbc.274.30.21409. PMID 10409703.
- ↑ "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell Sci. 116 (Pt 24): 4985–95. December 2003. doi:10.1242/jcs.00815. PMID 14625392.
- ↑ "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. 278 (19): 17269–76. May 2003. doi:10.1074/jbc.M211452200. PMID 12604612.
- ↑ "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen". J. Cell. Biochem. 73 (3): 390–9. 1999. doi:10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1. PMID 10321838.
- ↑ 16.0 16.1 "Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho". J. Cell Biol. 162 (1): 99–111. 2003. doi:10.1083/jcb.200211025. PMID 12835311.
- ↑ "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)". Biochem. Biophys. Res. Commun. 281 (2): 440–3. February 2001. doi:10.1006/bbrc.2001.4383. PMID 11181067.
- ↑ "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". Am. J. Pathol. 165 (3): 923–36. 2004. doi:10.1016/S0002-9440(10)63354-8. PMID 15331416.
- ↑ "Isolation of human delta-catenin and its binding specificity with presenilin 1". NeuroReport 10 (3): 563–8. February 1999. doi:10.1097/00001756-199902250-00022. PMID 10208590.
- ↑ "The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin". J. Biol. Chem. 275 (34): 26376–84. August 2000. doi:10.1074/jbc.M001315200. PMID 10835420.
- ↑ "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene 21 (46): 7067–76. October 2002. doi:10.1038/sj.onc.1205858. PMID 12370829.
- ↑ "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)". J. Biol. Chem. 275 (15): 11264–9. April 2000. doi:10.1074/jbc.275.15.11264. PMID 10753936.
- ↑ "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. 274 (1): 35–44. March 2002. doi:10.1006/excr.2001.5436. PMID 11855855.
- ↑ "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell Sci. 110 (17): 2065–77. September 1997. doi:10.1242/jcs.110.17.2065. PMID 9378757.
- ↑ "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor". Mol. Cell. Biol. 19 (5): 3614–23. May 1999. doi:10.1128/mcb.19.5.3614. PMID 10207085.
Further reading
- "E-cadherin-catenin cell-cell adhesion complex and human cancer". The British Journal of Surgery 87 (8): 992–1005. 2000. doi:10.1046/j.1365-2168.2000.01513.x. PMID 10931041. http://repub.eur.nl/pub/56571.
- "Altered expression of the catenin p120 in human cancer: implications for tumor progression". Differentiation 70 (9–10): 583–9. 2003. doi:10.1046/j.1432-0436.2002.700911.x. PMID 12492499.
- "Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer". Semin. Cell Dev. Biol. 15 (6): 657–63. 2005. doi:10.1016/j.semcdb.2004.09.003. PMID 15561585.
- "Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin". Cell Cycle 6 (2): 122–7. 2007. doi:10.4161/cc.6.2.3741. PMID 17264675.
- "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. 130 (2): 461–71. 1995. doi:10.1083/jcb.130.2.461. PMID 7542250.
- "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. 15 (9): 4819–24. 1995. doi:10.1128/mcb.15.9.4819. PMID 7651399.
- "Association of p120, a tyrosine kinase substrate, with E- cadherin/catenin complexes". J. Cell Biol. 128 (5): 949–57. 1995. doi:10.1083/jcb.128.5.949. PMID 7876318.
- "The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts". Exp. Cell Res. 225 (2): 328–37. 1996. doi:10.1006/excr.1996.0183. PMID 8660921.
- "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. 1997. doi:10.1093/dnares/4.2.141. PMID 9205841.
- "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell Sci. 110 (17): 2065–77. 1997. doi:10.1242/jcs.110.17.2065. PMID 9378757.
- "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. 273 (15): 9078–84. 1998. doi:10.1074/jbc.273.15.9078. PMID 9535896.
- "Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms". Genomics 50 (2): 129–46. 1998. doi:10.1006/geno.1998.5325. PMID 9653641.
- "Modification of the E-cadherin-catenin complex in mitotic Madin-Darby canine kidney epithelial cells". J. Biol. Chem. 273 (43): 28314–21. 1998. doi:10.1074/jbc.273.43.28314. PMID 9774455.
- "The Catenin p120ctn Interacts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor". Mol. Cell. Biol. 19 (5): 3614–23. 1999. doi:10.1128/mcb.19.5.3614. PMID 10207085.
- "p120ctn Acts as an Inhibitory Regulator of Cadherin Function in Colon Carcinoma Cells". J. Cell Biol. 145 (3): 551–62. 1999. doi:10.1083/jcb.145.3.551. PMID 10225956.
- "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen". J. Cell. Biochem. 73 (3): 390–9. 1999. doi:10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1. PMID 10321838.
- "Nuclear localization of the p120ctn Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression". Proc. Natl. Acad. Sci. U.S.A. 96 (14): 7980–5. 1999. doi:10.1073/pnas.96.14.7980. PMID 10393933.
- "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity". J. Biol. Chem. 274 (30): 21409–15. 1999. doi:10.1074/jbc.274.30.21409. PMID 10409703.
- "Selective Uncoupling of P120ctn from E-Cadherin Disrupts Strong Adhesion". J. Cell Biol. 148 (1): 189–202. 2000. doi:10.1083/jcb.148.1.189. PMID 10629228.
External links
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Wikimedia Commons has media related to P120 catenin. |
- Human CTNND1 genome location and CTNND1 gene details page in the UCSC Genome Browser.
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