Biology:ZBTB33

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene. This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

NAMED by Dr.Juliet Daniel's, the KAISO gene was named after 'calypso' music popular in the Caribbeans, Trinidad & Tobago, e.t.c.

Interactions

ZBTB33 has been shown to interact with HDAC3, Nuclear receptor co-repressor 1 and CTNND1.

Further reading

• "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor". Molecular and Cellular Biology 19 (5): 3614–23. May 1999. doi:10.1128/mcb.19.5.3614. PMID 10207085. 
• "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. Nov 2000. doi:10.1101/gr.143000. PMID 11076863. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor". Genes & Development 15 (13): 1613–8. Jul 2001. doi:10.1101/gad.198501. PMID 11445535. 
• "Monoclonal antibodies to Kaiso: a novel transcription factor and p120ctn-binding protein". Hybridoma 20 (3): 159–66. Jun 2001. doi:10.1089/027245701750293484. PMID 11461664. 
• "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell 12 (3): 723–34. Sep 2003. doi:10.1016/j.molcel.2003.08.008. PMID 14527417. 
• "Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells". The Journal of Biological Chemistry 279 (12): 11417–24. Mar 2004. doi:10.1074/jbc.M306057200. PMID 14699141. 
• "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. Oct 2004. doi:10.1101/gr.2576704. PMID 15489336. 
• "Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin". Nature Cell Biology 6 (12): 1212–20. Dec 2004. doi:10.1038/ncb1191. PMID 15543138. 
• "Kaiso is a genome-wide repressor of transcription that is essential for amphibian development". Development 131 (24): 6185–94. Dec 2004. doi:10.1242/dev.01549. PMID 15548582. 
• "Nuclear import of the BTB/POZ transcriptional regulator Kaiso". Journal of Cell Science 117 (Pt 25): 6143–52. Dec 2004. doi:10.1242/jcs.01541. PMID 15564377. 
• "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology 23 (1): 94–101. Jan 2005. doi:10.1038/nbt1046. PMID 15592455. 
• "Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment". Cancer Research 65 (6): 2224–33. Mar 2005. doi:10.1158/0008-5472.CAN-04-2020. PMID 15781635. 
• "The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin". Experimental Cell Research 305 (2): 253–65. May 2005. doi:10.1016/j.yexcr.2005.01.007. PMID 15817151. 
• "The tissue-specific methylation of the human tyrosine hydroxylase gene reveals new regulatory elements in the first exon". Journal of Neurochemistry 94 (1): 129–39. Jul 2005. doi:10.1111/j.1471-4159.2005.03173.x. PMID 15953356. 
• "The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso". The Journal of Biological Chemistry 280 (52): 43017–23. Dec 2005. doi:10.1074/jbc.M510802200. PMID 16230345. 

External links

• ZBTB33+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook ZBTB33
• ZBTB33 human gene location in the UCSC Genome Browser.
• ZBTB33 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.