Biology:PANK1

Generic protein structure example

Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene.

This gene encodes a protein belonging to the pantothenate kinase family, which in mammals is made of up PANK1, PANK2, PANK3, and PANK4. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified.

Further reading

• "Coenzyme A metabolism.". Am. J. Physiol. 248 (1 Pt 1): E1–9. 1985. doi:10.1152/ajpendo.1985.248.1.E1. PMID 2981478. 
• "Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.". J. Biol. Chem. 282 (38): 27984–93. 2007. doi:10.1074/jbc.M701915200. PMID 17631502. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. 2004. doi:10.1038/nature02462. PMID 15164054. 
• "PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression.". J. Lipid Res. 45 (1): 17–31. 2004. doi:10.1194/jlr.M300279-JLR200. PMID 14523052. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. 
• "In reference to the Short Communication published by Ni et al.". Int. J. Biochem. Cell Biol. 34 (12): 1629. 2003. doi:10.1016/S1357-2725(02)00125-5. PMID 12379284. 
• "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.". Nat. Genet. 28 (4): 345–9. 2001. doi:10.1038/ng572. PMID 11479594.