Biology:PCGEM1
From HandWiki
 Generic protein structure example |
| Prostate-specific transcript 1 | |
|---|---|
 Predicted secondary structure and sequence conservation of PCGEM1 | |
| Identifiers | |
| Symbol | PCGEM1 |
| Rfam | RF01981 |
| Other data | |
| RNA type | Gene; |
| Domain(s) | Eukaryota; |
| GO | 0042981 |
| SO | 0001463 |
| PDB structures | PDBe |
Prostate-specific transcript 1 (non-protein coding), also known as PCGEM1, is a long non-coding RNA gene. In humans, it is located on chromosome 2q32. It is over-expressed in prostate cancer.[1][2] In a study of prostate tumours from 88 men, levels of PCGEM1 were found to be higher in prostate cancer cells in African-American men than in Caucasian-American men. The mortality rate of prostate cancer is highest in African-American men.[3]
PCGEM1 inhibits doxorubicin-induced apoptosis of cells, via delayed induction of p53 and p21.[4]
See also
- Long noncoding RNA
- Prostate cancer
References
- ↑ "PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 12216–12221. October 2000. doi:10.1073/pnas.97.22.12216. PMID 11050243. Bibcode: 2000PNAS...9712216S.
- ↑ "Expression of human telomerase reverse transcriptase, Survivin, DD3 and PCGEM1 messenger RNA in archival prostate carcinoma tissue". Can J Urol 13 (1): 2967–2974. February 2006. PMID 16515751.
- ↑ "Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients". Oncogene 23 (2): 605–611. January 2004. doi:10.1038/sj.onc.1207069. PMID 14724589.
- ↑ "Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1". DNA Cell Biol. 25 (3): 135–141. March 2006. doi:10.1089/dna.2006.25.135. PMID 16569192.
Further reading
- "Differential effects of cholesterol and phytosterols on cell proliferation, apoptosis and expression of a prostate specific gene in prostate cancer cell lines.". Cancer Detect. Prev. 32 (4): 319–328. 2009. doi:10.1016/j.cdp.2008.12.002. PMID 19186008.
- "Risk of breast and prostate cancer is not associated with increased homozygosity in outbred populations.". Eur. J. Hum. Genet. 18 (8): 909–914. 2010. doi:10.1038/ejhg.2010.53. PMID 20407466.
- "LNCaP Atlas: gene expression associated with in vivo progression to castration-recurrent prostate cancer". BMC Med. Genom. 3: 43. 2010. doi:10.1186/1755-8794-3-43. PMID 20868494.
- "Prostate cancer gene expression marker 1 (PCGEM1): a patented prostate- specific non-coding gene and regulator of prostate cancer progression". Recent Pat DNA Gene Seq 3 (3): 151–163. November 2009. doi:10.2174/187221509789318360. PMID 19891595.
External links
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