Biology:PRKAG3
 Generic protein structure example |
5'-AMP-activated protein kinase subunit gamma-3 is an enzyme that in humans is encoded by the PRKAG3 gene.[1][2]
Function
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.[2]
References
- ↑ "A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle". Science 288 (5469): 1248–51. May 2000. doi:10.1126/science.288.5469.1248. PMID 10818001. Bibcode: 2000Sci...288.1248M.
- ↑ 2.0 2.1 "Entrez Gene: PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53632.
Further reading
- "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro". J. Biol. Chem. 271 (17): 10282–90. 1996. doi:10.1074/jbc.271.48.30517. PMID 8626596.
- "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". Biochem. J. 346 Pt 3 (3): 659–69. 2000. doi:10.1042/0264-6021:3460659. PMID 10698692.
- "5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle". J. Appl. Physiol. 94 (2): 631–41. 2003. doi:10.1152/japplphysiol.00642.2002. PMID 12391032.
- "A large-insert porcine library with sevenfold genome coverage: a tool for positional cloning of candidate genes for major quantitative traits". Mol. Cells 16 (1): 113–6. 2004. doi:10.1016/S1016-8478(23)13774-5. PMID 14503854.
- "Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle". Am. J. Physiol. Endocrinol. Metab. 286 (2): E194–200. 2004. doi:10.1152/ajpendo.00147.2003. PMID 14559719.
- "Comparative sequence analysis of the PRKAG3 region between human and pig: evolution of repetitive sequences and potential new exons". Cytogenet. Genome Res. 102 (1–4): 163–72. 2003. doi:10.1159/000075743. PMID 14970697.
- "Molecular characterization and mutational screening of the PRKAG3 gene in the horse". Cytogenet. Genome Res. 102 (1–4): 211–16. 2003. doi:10.1159/000075751. PMID 14970705.
- "Changes in exercise-induced gene expression in 5'-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice". Diabetes 54 (12): 3484–9. 2006. doi:10.2337/diabetes.54.12.3484. PMID 16306365.
- "Regulation of the muscle-specific AMP-activated protein kinase alpha2beta2gamma3 complexes by AMP and implications of the mutations in the gamma3-subunit for the AMP dependence of the enzyme". FEBS J. 274 (11): 2887–96. 2007. doi:10.1111/j.1742-4658.2007.05821.x. PMID 17518971.
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