Biology:PRPF4
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that is found in humans and encoded by the PRPF4 gene.[1][2][3]
The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors.
PRPF4 is 1 of several proteins that associates with U4 and U6 snRNPs.[supplied by OMIM][3]
References
- ↑ "The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p". RNA 3 (8): 926–41. Sep 1997. PMID 9257651.
- ↑ "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA 3 (12): 1374–87. Dec 1997. PMID 9404889.
- ↑ 3.0 3.1 "Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9128.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor.". Genes Dev. 11 (1): 139–51. 1997. doi:10.1101/gad.11.1.139. PMID 9000057.
- "Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome.". Hum. Mol. Genet. 6 (12): 2117–26. 1997. doi:10.1093/hmg/6.12.2117. PMID 9328476.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Mapping of the human HPRP3 and HPRP4 genes encoding U4/U6-associated splicing factors to chromosomes 1q21.1 and 9q31-q33.". Genomics 48 (2): 273–5. 1998. doi:10.1006/geno.1997.5181. PMID 9521884.
- "Cloning of human PRP4 reveals interaction with Clk1.". J. Biol. Chem. 276 (34): 32247–56. 2001. doi:10.1074/jbc.M103790200. PMID 11418604.
- "Central region of the human splicing factor Hprp3p interacts with Hprp4p.". J. Biol. Chem. 277 (26): 23764–72. 2002. doi:10.1074/jbc.M111461200. PMID 11971898.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide.". J. Mol. Biol. 331 (1): 45–56. 2003. doi:10.1016/S0022-2836(03)00684-3. PMID 12875835. http://pubman.mpdl.mpg.de/pubman/item/escidoc:599390/component/escidoc:599389/244851.pdf.
- "Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH.". Nucleic Acids Res. 31 (16): 4791–6. 2004. doi:10.1093/nar/gkg660. PMID 12907720.
- "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer.". J. Cell Biol. 166 (7): 1015–25. 2004. doi:10.1083/jcb.200405160. PMID 15452143.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.". RNA 12 (7): 1418–30. 2006. doi:10.1261/rna.55406. PMID 16723661.
- "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.". J. Immunol. 178 (11): 7081–7. 2007. doi:10.4049/jimmunol.178.11.7081. PMID 17513757.
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