Biology:Polyuridylation
From HandWiki
Polyuridylation, also called oligouridylation, is the addition of several uridine nucleotides to the 3' end of an RNA. Cytoplasmic poly(U) polymerases can add uridine nucleotides to both coding and non-coding RNAs. This addition may occur throughout a variety of RNA types including mRNAs, small RNAs, miRNAs, siRNAs, guide RNAs, or piRNAs.[1] Polyuridylation has been shown to play a role in gene regulation as an evolutionarily conserved process in eukaryotes.[2]
One group of RNAs that can be polyuridylated are histone mRNAs that lack a poly(A) tail. Polyuridylation of a histone mRNA promotes its degradation, involving the exosome. Other RNAs in Arabidopsis and mouse have been seen to be polyuridinylated after cleavage.[3]
References
- ↑ "Polyuridylation in Eukaryotes: A 3'-End Modification Regulating RNA Life". BioMed Research International 2015. 15 April 2015. doi:10.1155/2015/968127. PMID 26078976.
- ↑ "Efficient RNA polyuridylation by noncanonical poly(A) polymerases". Molecular and Cellular Biology 27 (10): 3612–3624. May 2007. doi:10.1128/MCB.02209-06. PMID 17353264.
- ↑ "New ways to meet your (3') end oligouridylation as a step on the path to destruction". Genes & Development 22 (1): 1–7. January 2008. doi:10.1101/gad.1634508. PMID 18172159.
 |  |
