Biology:Polyenoic fatty acid isomerase
| Polyenoic fatty acid isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.3.3.13 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, a polyenoic fatty acid isomerase (EC 5.3.3.13) is an enzyme that catalyzes the chemical reaction
- (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate [math]\displaystyle{ \rightleftharpoons }[/math] (5Z,7E,9E,14Z,17Z)-icosapentaenoate
Hence, this enzyme has one substrate, (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate, and one product, (5Z,7E,9E,14Z,17Z)-icosapentaenoate.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Delta8,11-Delta7,9-isomerase (trans-double-bond-forming). Other names in common use include PFI, eicosapentaenoate cis-Delta5,8,11,14,17-eicosapentaenoate, cis-Delta5-trans-Delta7,9-cis-Delta14,17 isomerase, (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,8-isomerase, (incorrect), (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,9-isomerase, and (trans-double-bond-forming).
References
- "Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina". Biochemistry 33 (51): 15223–32. 1994. doi:10.1021/bi00255a002. PMID 7803384.
- "Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid". Experientia 52 (1): 88–92. 1996. doi:10.1007/BF01922423. PMID 8575565.
- "Characterization of the substrate binding site of polyenoic fatty acid isomerase, a novel enzyme from the marine alga Ptilota filicina". Biochemistry 36 (10): 2985–92. 1997. doi:10.1021/bi962158v. PMID 9062129.
- "Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA". Arch. Biochem. Biophys. 401 (1): 11–20. 2002. doi:10.1016/S0003-9861(02)00002-4. PMID 12054482.
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